713121-80-3
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基本信息
ML193 trifluoroacetate >=98% (HPLC)
N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide
4-Quinolinecarboxamide, N-[4-[[(3,4-dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價(jià)格 |
2025/02/08 | HY-110125 | ML-193 | 713121-80-3 | 1 mg | 400元 |
2025/02/08 | HY-110125 | ML193 ML-193 | 713121-80-3 | 5mg | 850元 |
2025/02/08 | HY-110125 | ML193 ML-193 | 713121-80-3 | 10 mM * 1 mLin DMSO | 987元 |
常見問題列表
IC50: 221 nM (GPR55)
ML-193 (0.01-100 μM; pretreated for 15 min) inhibits β-arrestin trafficking induced by L-α-lysophophosphatidylinositol (LPI, 10 μM) and ML186 (1 μM) with IC
50
s of 0.22 μM and 0.12 μM, respectively.
ML-193 (0.01-10 μM; pretreated for 30 min) decreases the LPI-mediated ERK1/2 phosphorylation, with an IC
50
of 0.2 μM in U2OS cells.
ML-193 (5 μM; pretreated for 30 min) attenuates the GPR55 agonists induced increases in hNSCs proliferation rates.
ML-193 (5 μM; 10 d) attenuates the ML184-induced increases in hNSCs differentiation.
ML193 (1 and 5 μg/rat; intra-striatal at a rate of 1 μL/min) attenuates sensorimotor deficits and slip steps, increases motor coordination in PD rats.
Animal Model: | Male Wistar rats (200-250 g) were induced experimental Parkinson by 6-hydroxydopamine (6-OHDA, 10 μg/rat) |
Dosage: | 1 and 5 μg/rat |
Administration: | Injected into the right striatum at a rate of 1 μL/min |
Result: | Increased the time on the rotarod, decreased latency to remove the label and slip steps in 6-OHDA-lesioned rats. |