1357171-62-0
中文名稱(chēng)
KC7F2
英文名稱(chēng)
ML-228
CAS
1357171-62-0
分子式
C27H21N5
分子量
415.49
MOL 文件
1357171-62-0.mol
更新日期
2025/03/12 16:18:22
1357171-62-0 結(jié)構(gòu)式
基本信息
中文別名
化合物ML228 英文別名
L-228ML-228
CID-46742353
ML228
ML 228
ML-228
CID-46742353
N-([1,1'Biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-1,2,4-triazin-5-amine
N-([1,1-Biphenyl]-4-ylmethyl)-6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-5-amine
1,2,4-Triazin-5-amine, N-([1,1'-biphenyl]-4-ylmethyl)-6-phenyl-3-(2-pyridinyl)-
所屬類(lèi)別
生物化工：激動(dòng)劑抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)686.0±65.0 °C(Predicted)
密度1.228±0.06 g/cm3(Predicted)
儲(chǔ)存條件-20°C, Inert atmosphere
溶解度可溶于DMSO（少許）、甲醇（少許）
酸度系數(shù)(pKa)2.03±0.63(Predicted)
形態(tài)固體
顏色淡黃色至淡黃色
KC7F2價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
| 2025/02/08 | HY-12754 | ML228 | 1357171-62-0 | 1 mg | 450元 |
| 2025/02/08 | HY-12754 | KC7F2 ML228 | 1357171-62-0 | 5mg | 990元 |
| 2025/02/08 | HY-12754 | KC7F2 ML228 | 1357171-62-0 | 10mM * 1mLin DMSO | 1089元 |
常見(jiàn)問(wèn)題列表
生物活性
ML228 (CID-46742353) 是一種有效的 HIF 信號(hào)通路激活劑，EC50 為 1 μM。ML228 可激活 HIF 以及下游 EGFR。靶點(diǎn)
EC50: 1 μM (HIF)
體外研究
ML228 (CID-46742353) represents a novel chemotype available to the research community for the study of HIF activation and its therapeutic potential. Not only is the compound substantially different in structure from known HIF activators, ML228 lacks the acidic functional group almost universally present in PHD inhibitors, which may be important for certain disease applications.
體內(nèi)研究
ML228 (injection; 1 μg/kg; 7 days) treatments following spinal cord injury (SCI) improves the local hypoxic ischemia environment, reduce SCI secondary injury and promote the recovery of neurological function.
| Animal Model: | SD rat |
| Dosage: | 1 μg/kg |
| Administration: | injection; 7 days |
| Result: | Alleviated SCI of the central nervous system and relieve associated symptoms. |