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64-47-1

中文名稱 硫酸依色林
英文名稱 ESERINE SULFATE
CAS 64-47-1
EINECS 編號(hào) 200-585-4
分子式 C30H44N6O8S
MDL 編號(hào) MFCD06795853
分子量 648.77
MOL 文件 64-47-1.mol
64-47-1 結(jié)構(gòu)式 64-47-1 結(jié)構(gòu)式

基本信息

中文別名
硫酸毒豆堿
硫酸依色林
毒扁豆堿硫酸鹽
依色林硫酸鹽
英文別名
(3AS)-CIS-1,2,3,3A,8,8A-HEXAHYDRO-1,3A,8-TRIMETHYLPYRROLO[2,3-B]INDOL-5-OL METHYLCARBAMATE HEMISULFATE
ESERINE HEMISULFATE
ESERINE HEMISULFATE SALT
ESERINE SULFATE
PHYSOSTIGMINE HEMISULFATE
PHYSOSTIGMINE HEMISULFATE SALT
PHYSOSTIGMINE SULFATE
(3as-cis)-amate(estersulfate(2:1)(salt)
(3as-cis)-ylcarbamate(estersulfate(2:1)
3-b)indole,1,2,3,3a,8,8a-hexahydro-5-hydroxy-1,3a,8-trimethyl-pyrrolo(meth
eserinesulphate
physostigmineso4
physostigminesulphate
Pyrrolo2,3-bindol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-, sulfate (2:1) (salt)
PHYSOSOTIGMINESULPHATE
Physostigminsulfat
(3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol methylcarbamate hemisulfate

物理化學(xué)性質(zhì)

熔點(diǎn)140° (after drying at 100°)
密度1.0911 (rough estimate)
折射率1.7000 (estimate)
儲(chǔ)存條件2-8°C
儲(chǔ)存條件2-8°C
溶解度DMSO(微溶)、乙醇(微溶)、甲醇(微溶)
形態(tài)粉末
顏色White to off-white
水溶解性溶于水至100mM
Merck13,7469
穩(wěn)定性吸濕性
CAS 數(shù)據(jù)庫(kù)64-47-1(CAS DataBase Reference)
EPA化學(xué)物質(zhì)信息Physostigmine sulfate (2:1) (64-47-1)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H300+H330
危險(xiǎn)品標(biāo)志T+
危險(xiǎn)類別碼26/28
危險(xiǎn)類別碼R26/28
安全說(shuō)明25-45
安全說(shuō)明S25-S45
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 1
危險(xiǎn)品運(yùn)輸編號(hào)UN 2811 6.1/PG 1
WGK Germany3
WGK Germany3
RTECS號(hào)UY8585000
危險(xiǎn)等級(jí)6.1(a)
包裝類別II

知名試劑公司產(chǎn)品信息

常見問(wèn)題列表

生物活性
Physostigmine hemisulfate (Eserine hemisulfate) 是一種可逆的乙酰膽堿酯酶 (AChE) 抑制劑。Physostigmine hemisulfate 可以透過(guò)血腦屏障并刺激中樞膽堿能神經(jīng)傳遞。Physostigmine hemisulfate 能逆轉(zhuǎn)阿爾茨海默病轉(zhuǎn)基因小鼠的記憶缺陷。Physostigmine hemisulfate 也是抗膽堿能中毒的解毒劑。
體內(nèi)研究

Physostigmine hemisulfate (Eserine hemisulfate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice.
Physostigmine hemisulfate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats.

Animal Model: Heterozygous transgenic mice (Tg(+) mice)
Dosage: 0.03, 0.1, and 0.3 mg/kg
Administration: SC; daily for 6 weeks
Result: Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.
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