6326-06-3
6326-06-3 結構式
基本信息
Benzenesulfonamide, 4-methyl-N-9H-xanthen-9-yl-
4-Methyl-N-(9H-xanthen-9-yl)-benzenesulfonamide
物理化學性質
常見問題列表
pIC50: 7.1 (human FFA4)
AH-7614 (compound 39) (0.063-1 μM) blocks intracellular Ca
2+
response induced by both linoleic acid and FFAR4 agonist in FFA4 expressing U2OS cells.
AH-7614 (100 μM) abolishes the enhancement in glucose-stimulated insulin secretion by GSK137647A in NCI-H716 cells.
AH-7614 (0.001-10 μM; 15 min) blocks TUG-891-mediated internalization of FFA4 from the cell surface (pIC
50
=7.70).
AH-7614 (10 μM; 30 min) blocks agonist-induced elevation of intracellular inositol monophosphates and phosphorylation of FFA4.
AH7614 (50?μg; intratumoral injection once every 4?d for 20 d) reduces the tumor growth in mice.
AH7614 (50?μg; intratumoral injection one day prior to epirubicin injection) enhances cancer cell sensitivity to the chemotherapy and inhibit tumor progression by blocking GPR120 signaling in combination with Epirubicin.