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55721-31-8

中文名稱 鹽霉素
英文名稱 Salinomycin
CAS 55721-31-8
分子式 C42H71NaO12
分子量 791
MOL 文件 55721-31-8.mol
更新日期 2025/01/20 11:34:34
55721-31-8 結(jié)構(gòu)式 55721-31-8 結(jié)構(gòu)式

基本信息

中文別名
鹽霉素
沙利諾馬辛
沙利霉素鈉
鹽霉素鈉鹽
鹽霉素預(yù)混
鹽霉素 單鈉鹽 水合物
鹽霉素SV鈉鹽的五個半水合物
英文別名
Salinomycin
Salinomycin-Natrium
Salinomycin 1-sodium salt
Salinomycin sodium premix
Salinomycin, monosodium salt
SalinoMycin SodiuM Salt (12% Min.)
SalinoMycin 12% 24% HOUSE STANDARD
salinomycin monosodium salt hydrate
SALINOMYCIN SODIUM SALT 2.5-HYDRATE
Salinomycin hydrate monosodium salt
所屬類別
飼料添加劑: 驅(qū)蟲保健劑

物理化學(xué)性質(zhì)

外觀性狀白色或淡黃色結(jié)晶性粉末,微有特異臭,熔點140-142℃。易溶于丙酮、三氯甲烷、苯、乙酸乙酯、乙醚和甲醇,幾乎不溶于水。大白鼠經(jīng)口LD5070-100mg/kg,小白鼠經(jīng)口LD5050mg/kg,雞LD50150mg/kg。
熔點140-142°
比旋光度D25 -37° (c = 1 in ethanol)
儲存條件APPROX 4°C
溶解度溶于二甲基亞砜。
形態(tài)neat
顏色白色
Merck13,8415
BRN4901827
穩(wěn)定性DMSO中的溶液可在-20°下穩(wěn)定儲存3個月。

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS06
警示詞危險
危險性描述H301
危險品標(biāo)志T
危險類別碼25
安全說明45
危險品運輸編號2811
WGK Germany3
危險等級6.1
包裝類別III

制備方法

方法1
由白色鏈霉菌(Streptomyces albus)發(fā)酵生產(chǎn)。

上下游產(chǎn)品信息

上游原料
酒石酸銨

應(yīng)用領(lǐng)域

參考質(zhì)量標(biāo)準(zhǔn)
農(nóng)業(yè)部標(biāo)準(zhǔn)(暫行)
原料:
含量(干基),效價/(μg/mg)
≥800
澄清度(1g+20mL甲醇)
澄清
灼燒殘渣/%
7.0~12.0
干燥失重(60℃減壓干燥)/%
≤7.0
重金屬(以Pb計)/%
≤0.002
砷(以As計)/%
≤0.0004
預(yù)混劑:
含量(標(biāo)示量的)/%
85.0~125.0
外觀
淡黃色粉
細度(過1號篩)/%
100
干燥失重(60℃減壓干燥)/%
≤12.0

常見問題列表

生物活性
Salinomycin sodium salt (Salinomycin sodium),一種鉀離子載體抗生素,是 Wnt/β-catenin 信號傳導(dǎo)的有效抑制劑。Salinomycin sodium salt (Salinomycin sodium) 作用于 Wnt/Fzd/LRP 復(fù)合物,阻斷 Wnt 誘導(dǎo)的 LRP6 磷酸化,導(dǎo)致 LRP6 蛋白降解。Salinomycin sodium salt (Salinomycin sodium) 選擇性抑制人腫瘤干細胞。
靶點

Wnt/β-catenin

體外研究

Salinomycin (0.1-8 μM) inhibits the growth of HUVECs in a dose-dependent manner, accounting for 32.1 and 59.2% inhibition at 4 and 8 μM, respectively. HUVECs exposed to 2, 4 and 8 μM of Salinomycin for 48 h show a dose-dependent reduction in cell number and a change in cell morphology. Salinomycin (4 μM) treatment effectively inhibits HUVEC migration and invasion, and significantly disrupt the capillary-like tube formation of HUVECs. Salinomycin significantly suppresses the expression levels of phosphorylated (p)-FAK in a time- and dose-dependent manner in HUVECs. Salinomycin inhibits HUVEC angiogenesis by disturbing the VEGF-VEGFR2-AKT signaling axis. Combination of RSVL and Salinomycin synergistically inhibits the proliferation of TNBC (MDA-MB-231) cells. RSVL and Salinomycin effectively reduce wound healing, colony and tumorosphere forming capability in TNBC cells. Synergistic combination of RSVL and Salinomycin induces apoptosis in both culture conditions by significant upregulation of Bax with decreased Bcl-2 expression as comparison to untreated and alone drug treatments. Salinomycin (0, 2, 4, 8 and 16 μM) significantly inhibits the proliferation of A2780 and SK-OV-3 cell lines in a dose- and time-dependent manner, (IC 50 24h : 13.8 μM, IC 50 48h : 6.888 μM and IC 50 72h : 4.382 μM for A2780 cell lines), (IC 50 24h : 12.7 μM, IC 50 48h : 9.869 μM and IC 50 72h : 5.022 μM for SK-OV-3 cell lines). Salinomycin blocks the Wnt/β-catenin pathway in EOC cells. Salinomycin (2 μM) reduces cancer cell proliferation, inhibits STAT3 phosphorylation and P38 and β-catenin expressions, and suppresses epithelial-mesenchymal transition in colorectal cancer cells. Salinomycin (1-5 μM) inhibits cancer cell proliferation and STAT3 signaling in colorectal cancer cells. Furthermore, Salinomycin activates Akt (Ser 473) and down-regulates Hsp27 (Ser 82) phosphorylation in HT-29 and SW480. Salinomycin down-regulates hTERT and reduces telomerase activity when combined with telomerase inhibitor.

體內(nèi)研究

Salinomycin (5 and 10 mg/kg) significantly supresses the average tumor volume and tumor weight. Salinomycin hinders the U251 human glioma cell growth in vivo via inhibition of angiogenesis with involvement of AKT and FAK dephosphorylation. Salinomycin (0.5 mg/kg b.wt.) enhances the mean survival time of the tumor bearing Swiss albino mice.

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