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54739-18-3

中文名稱(chēng) 氟伏沙明
英文名稱(chēng) Fluvoxamine
CAS 54739-18-3
分子式 C15H21F3N2O2
MDL 編號(hào) MFCD00865345
分子量 318.33
MOL 文件 54739-18-3.mol
54739-18-3 結(jié)構(gòu)式 54739-18-3 結(jié)構(gòu)式

基本信息

中文別名
(E)-5-甲氧基-4-三氟甲基苯戊酮氧-2-氨乙?;?BR>氟伏沙明
氟提肟氨
英文別名
2-[[5-methoxy-1-[4-(trifluoromethyl)phenyl]-pentylidene]amino]oxyethanamine
FLUVOXAMINE
(E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]-1-pentanoneo-(2-aminoethyl)oxime
(1E)-5-Methoxy-1-[4-(trifluoromethyl)phenyl]pentanal O-(2-aminoethyl)oxime
(E)-ω-Methoxy-4'-(trifluoromethyl)valerophenone O-(2-aminoethyl)oxime
δ-Methoxy-4'-(trifluoromethyl)valerophenone (E)-O-(2-aminoethyl)oxime
所屬類(lèi)別
原料藥:抗抑郁、躁狂藥

物理化學(xué)性質(zhì)

熔點(diǎn)120-122.5°C
沸點(diǎn)370.6±52.0 °C(Predicted)
密度1.16±0.1 g/cm3(Predicted)
儲(chǔ)存條件Sealed in dry,2-8°C
溶解度可溶于氯仿(少量)、DMSO(少量)、甲醇(少量)
酸度系數(shù)(pKa)pKa 8.7 (Uncertain)
形態(tài)Oil
顏色無(wú)色
CAS 數(shù)據(jù)庫(kù)54739-18-3(CAS DataBase Reference)
NIST化學(xué)物質(zhì)信息Fluvoxamine(54739-18-3)

安全數(shù)據(jù)

常見(jiàn)問(wèn)題列表

生物活性
Fluvoxamine (DU-23000) 是5-羥色胺再吸收抑制劑,有抗抑郁活性。
靶點(diǎn)

SSRIs.

體內(nèi)研究

Fluvoxamine (DU-23000) is effective in inhibiting 5-ht uptake by blood platelets and brain synaptosomes. The antagonism by fluvoxamine of the reserpine-induced lowering of the pentamethylenetetrazole convulsive threshold can be regarded as due to an effect upon 5-HT uptake. In contrast to the effects of desmethylimipramine and imipramine, no stimulatory effects are found in rats when rapidly acting reserpine-like compounds are given following a dose of fluvoxamine. Fluvoxamine (DU-23000) appears to improve combat-related PTSD symptoms but not depressive symptoms. The high attrition rate and lack of a placebo group limits the conclusions of our study. Controlled studies of fluvoxamine in the treatment of PTSD are warranted. Fluvoxamine (DU-23000) was less potent at decreasing ethanol self-administration when food was available concurrently versus when ethanol was available in isolation [ED50: 4.0 (2.7-5.9) and 5.1 (4.3-6.0)]. Effects on food were similar under each condition in which food was available. The results demonstrate that the potency of fluvoxamine in reducing ethanol-maintained behavior depends on whether ethanol is available in isolation or in the context of concurrently scheduled food reinforcement.

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