518-69-4
518-69-4 結構式
基本信息
紫堇堿
延胡索堿
延胡索堿甲
延胡索甲素
紫堇堿,延胡索堿,
延胡索甲素(紫堇堿)
延胡索甲素(標準品)
延胡索堿(紫堇塊莖堿)
(+)-紫堇堿,延胡索甲素
CORYDALINE
Corydalis A
(13s-e)-thyl
d-Corydaline
(+) CORYDALINE
Corydaline std.
CORYDALINE, (+)
2,3,9,10-tetramethoxy-13-methyl-berbin
2,3,9,10-TetraMethoxy-13-Methylberbine, 8CI
物理化學性質
安全數據
常見問題列表
延胡索甲素為季胺類生物堿，是罌粟科紫堇屬植物延胡索(Corydalis yanhusuo W.T.Wang)塊莖中的主要有效成分之一。現代藥理學表明延胡索甲素不僅有鎮(zhèn)痛、興奮子 宮、抗心律失常等作用，延胡索甲素具有抗嗎啡樣作用，還可用于制備為戒毒藥物。
延胡索甲素在無毒性范圍內能夠有效地抑制呼吸道病毒的復制，可進一步開發(fā)為治療或預防病毒性呼吸道疾病的藥物，具有廣泛的應用前景。
IC50: 226 μM (AChE); 25.23 μM (Enterovirus 71)
Ki: 1.23 μM (μ-opioid receptor)
Corydaline (12.5-50 μM; 24 hours) treatment inhibits EV71 replication by suppressing the COX-2 expression and the phosphorylation of JNK MAPK and P38 MAPK but not ERK MAPK in vitro.
Corydaline could inhibit the viral RNA synthesis in a dose dependent manner.
Western Blot Analysis
| Cell Line: | Vero cells infected with EV71 |
| Concentration: | 12.5 μM, 25 μM, 50 μM |
| Incubation Time: | 24 hours |
| Result: | Reduced the phosphorylation of P38 MAPK and JNK MAPK and the expression of COX-2. |
Corydaline (10 mg/kg; subcutaneous administration; once) treatment shows antinociceptive effects in mice by significantly inhibiting the writhing behavior.
| Animal Model: | Male CD1 mice (30-35 g, 7-8 weeks old) injected with acetic acid |
| Dosage: | 10 mg/kg |
| Administration: | Subcutaneous administration; once |
| Result: | Showed antinociceptive effects in mice. |