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41570-61-0

中文名稱 妥布特羅
英文名稱 Tulobuterol
CAS 41570-61-0
分子式 C12H18ClNO
MDL 編號 MFCD00867022
分子量 227.73
MOL 文件 41570-61-0.mol
更新日期 2024/11/20 10:26:13
41570-61-0 結(jié)構(gòu)式 41570-61-0 結(jié)構(gòu)式

基本信息

中文別名
alpha-[(叔丁基氨基)甲基]-鄰氯苯甲醇
妥布特羅
妥洛特羅
英文別名
alpha-[(tert-butylamino)methyl]-o-chlorobenzyl alcohol
TULOBUTEROL
TULOBUTEROL BASE
TulobuterolHcl56776-01-3/Base
Tulobuterol(baseandorunspecifiedsalt)
2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethano
Benzenemethanol, 2-chloro-a-[[(1,1-dimethylethyl)amino]methyl]- (9CI)
HN 078
o-Chloro-a-[(tert-butylamino)methyl]benzyl alcohol
Tulobuterol Bane
Tulobuterol (base and/or unspecified salts)
2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol
2-(tert-Butylamino)-1-(o-chlorophenyl)ethanol
Sekinarin
Tulobunist
Tulobuten
α-[(tert-Butylamino)methyl]-2-chlorobenzenemethanol
所屬類別
原料藥:平喘藥

物理化學(xué)性質(zhì)

熔點(diǎn)89-91°C
沸點(diǎn)338.2±27.0 °C(Predicted)
密度1.098±0.06 g/cm3(Predicted)
RTECS號DA4734170
儲存條件-20°C冷凍
溶解度可溶于DMSO(少許)、甲醇(少許)
酸度系數(shù)(pKa)13.62±0.20(Predicted)
形態(tài)固體
顏色白色至灰白色
CAS 數(shù)據(jù)庫41570-61-0(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H302
安全說明24/25
海關(guān)編碼29214990
毒性LD50 in male mice, rats, rabbits (mg/kg): 305, 850, 563 orally; 170, 417, 164 s.c. (Kubo, 1975)
妥布特羅價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/08XW024157061004妥布特羅41570-61-025G5919元
2024/11/08HY-B1810妥布特羅
Tulobuterol
41570-61-050mg700元
2024/11/08XW024157061003妥布特羅41570-61-010G2546元

常見問題列表

生物活性
Tulobuterol (C-78 free base) 是一種長效的 β2 腎上腺素受體 (β2-adrenoceptor) 激動劑,可減少慢性阻塞性肺疾病和支氣管哮喘的發(fā)作頻率。Tulobuterol 也是一種擬交感神經(jīng)藥,用作透皮貼劑,可增加正常的橫膈膜肌肉力量。
靶點(diǎn)

β2-adrenoceptor

體外研究

Tulobuterol (0.1 μM; 24 hours or 72 hours; human tracheal epithelial cells) treatment decreases the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells treated with tulobutero are significantly lower than those in the cells treated with vehicle before RV14 infection. Treatment with Tulobuterol reduces the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduces the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. Tulobuterol treatment produces a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.

RT-PCR

Cell Line: Human tracheal epithelial cells infected with RV14
Concentration: 0.1 μM
Incubation Time: 24 hours or 72 hours
Result: Decreased the RV14 RNA levels at 1 day and at 3 days after infection. The concentrations of sICAM-1 in the supernatants of the cells were significantly lower. Reduced the number of acidic endosomes with green fluorescence in the cells and the fluorescence intensity of acidic endosomes in the cells. Also reduced the RV14 infection-induced secretion of IL-1β, IL-6, and IL-8. And produced a small but significant reduction in the amount of p50, p65, and c-Rel of NF-κB induced by RV14 infection.
體內(nèi)研究

In vivo effect of Tulobuterol is examined the on the contractility of diaphragm muscles prepared from mice (BALBs/c mice; 21.7 ± 0.2 g) treated with Endotoxin. Contractile parameters of force-frequency curves and twitch kinetics using untreated or treated diaphragm muscles at 0 (E0) and 4 (E4) hours after E. coli endotoxin (20 mg/kg) administration are measured. E0 and E4 diaphragm muscles are analyzed at 0, 12, and 24 h after transdermal Tulobuterol treatment. The force-frequency curves of E0 and E4 diaphragm muscles at three time points are not significantly changed each other, indicating that Tulobuterol patch restores the muscle contractility. Thus, diaphragm muscle contractility is maintained during 4 h of endotoxin administration with Tulobuterol patch for over 24 h.

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