41443-28-1
中文名稱(chēng)
1H-[1,2,4]惡草靈并[4,3-A]喹喔啉-1-酮
英文名稱(chēng)
ODQ
CAS
41443-28-1
分子式
C9H5N3O2
MDL 編號(hào)
MFCD00792620
分子量
187.15
MOL 文件
41443-28-1.mol
更新日期
2024/10/29 10:09:23
41443-28-1 結(jié)構(gòu)式
基本信息
中文別名
1H- [1,2,4]惡二唑[4,3-A]喹喔啉-1-酮1H-[1,2,4]噁二唑并[4,3-A]喹喔啉-1-酮
1H-[1,2,4]惡二唑并[4,3-A]喹喔啉-1-酮
1H-[1,2,4]惡二唑并[4,3-A]喹惡啉-1-酮
1H-[1,2,4]惡草靈并[4,3-A]喹喔啉-1-酮
英文別名
ODQ 所屬類(lèi)別
有機(jī)原料：酮類(lèi)化合物物理化學(xué)性質(zhì)
熔點(diǎn)160-170 °C
熔點(diǎn)160-170 °C
沸點(diǎn)321.89°C (rough estimate)
密度1.3753 (rough estimate)
RTECS號(hào)RO0913150
折射率1.6500 (estimate)
儲(chǔ)存條件2-8°C
儲(chǔ)存條件2-8°C
溶解度ethanol: 1.2 mg/mL
溶解度乙醇：1.2 mg/mL
酸度系數(shù)(pKa)0.94±0.20(Predicted)
形態(tài)powder
形態(tài)粉末
顏色pale yellow
顏色淡黃色
穩(wěn)定性DMSO中的溶液可在-20°下穩(wěn)定儲(chǔ)存3個(gè)月。
CAS 數(shù)據(jù)庫(kù)41443-28-1(CAS DataBase Reference)
安全數(shù)據(jù)
常見(jiàn)問(wèn)題列表
生物活性
ODQ (1H-ODQ) 是一種有效的和選擇性的 soluble guanylyl cyclase (sGC, nitric oxide-activated enzyme) 的抑制劑，可增強(qiáng)順鉑在人類(lèi)間皮瘤細(xì)胞中的促凋亡作用。靶點(diǎn)
| Target | Value |
|
sGC
() |
體外研究
At 30 and 50 μM, ODQ causes significant induction of apoptosis in the NCI-H2452 cells, elevating apoptotic levels by 12 fold and 15 fold, respectively. At 10μM, a concentration below the threshold for induction of apoptosis by ODQ, ODQ in combination with Cisplatin enhanced (in fact, doubled) the pro-apoptotic effects of Cisplatin at 1 μM.
體內(nèi)研究
ODQ (2 mg/kg; i.p.) reduces the multiple organ injury and dysfunction caused by wall fragments of Gram-positive or Gram-negative bacteria in the anesthetized rat.
| Animal Model: | Anesthetized, male Wistar rats |
| Dosage: | 2 mg/kg |
| Administration: | I.p. |
| Result: | Attenuated the renal dysfunction, lung injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide. |