379270-38-9
379270-38-9 結(jié)構(gòu)式
基本信息
富馬酸GS-7340
泰諾福韋艾拉酚胺半鹽
GS 7340 富馬酸鹽
替諾福韋丙氨芬胺富馬酸鹽
泰諾福韋艾拉酚胺富馬酸鹽
替諾福韋艾拉酚胺富馬酸單鹽
替諾福韋阿拉芬酰胺富馬酸酯
替諾福韋艾拉酚胺富馬酸鹽[單鹽]
替諾福韋艾拉酚胺富馬酸鹽(1:1)
GS-7340 (fuMarate)
Tenofovir alafenamide-19
tenofovir alafenamide fumarate (TAF)
Tenofovir alafenamide : fumarate = 1:1)
Tenofovir alafenamide fumarate (GS-7340)
Tenofovir alafenamide fumarate (1:1 salt)
TENOFOVIR ALAFENAMIDE FUMARATE (GS-7340 FUMARATE)
L-Alanine,N-[(S)-[[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylet...
isopropyl ((S)-((((R)-1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)(phenoxy)phosphoryl)-L-alaninate fumarate
物理化學(xué)性質(zhì)
Ethanol:100.0(Max Conc. mg/mL);168.48(Max Conc. mM)
Water:17.5(Max Conc. mg/mL);29.48(Max Conc. mM)
常見(jiàn)問(wèn)題列表
HIV-1, NRTIs
Tenofovir alafenamide fumarate (GS-7340 fumarate) antiviral activities are similar across all cell types, ranging from 5 to 7 nM, while the CC 50 varies from 4.7 to 42 μM for MT-4 and MT-2 cells, respectively. The antiviral activity of TAF is evaluated against a panel of HIV-1 and HIV-2 isolates, including HIV-1 group M subtypes A to G, as well as group N and O isolates. Overall, for the 29 primary HIV-1 isolates tested in PBMCs, TAF EC 50 s range from 0.1 to 12 nM, with a mean EC 50 of 3.5 nM compared to a mean EC 50 of 11.8 nM for AZT, which is used as an internal control. For the HIV-2 isolates, the mean EC 50 s are 1.8 nM for TAF and 6.4 nM for AZT.
Tenofovir alafenamide fumarate (GS-7340 fumarate) is an amidate prodrug of Tenofovir with good oral bioavailability and increases plasma stability compared to Tenofovir disoproxil fumarate (TDF).