3546-03-0
基本信息
賽馬咪嗪
賽馬咪嗪雜質(zhì)
氰美馬嗪雜質(zhì)
RP-7204
Tercian
7204 RP
CiaMatil
Cianatil
CyaMeMazin
F. I. 6229
7204 R. E.
cyamemazine
物理化學(xué)性質(zhì)
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/08 | HY-14264 | 氰美馬嗪 Cyamemazine | 3546-03-0 | 5mg | 800元 |
2024/11/08 | HY-14264 | 氰美馬嗪 Cyamemazine | 3546-03-0 | 10 mM * 1 mLin DMSO | 880元 |
2024/11/08 | HY-14264 | 氰美馬嗪 Cyamemazine | 3546-03-0 | 10mg | 1300元 |
常見問題列表
5-HT 2A Receptor 1.5 nM (Ki) |
5-HT 2C Receptor 12 nM (Ki) |
5-HT 3 Receptor 75 nM (Ki) |
Cyamemazine exhibits a high affinity for dopamine receptors, which is consistent with its antipsychotic activity. The antagonist activity of Cyamemazine at muscarinic receptors is consistent with its affinity for M 1 ( K i = 13 nM), M 2 ( K i = 42 nM), M 3 ( K i = 321 nM), M 4 ( K i = 12 nM), and M 5 ( K i = 35 nM) receptors.
Cyamemazine behaves as an antagonist at the 5-HT 3 , 5-HT 2C , and 5-HT 2A receptors in 5-HT 3 -dependent contraction of isolated guinea pig ileum and bradycardic responses in rats, in 5-HT 2C -dependent phospholipase C stimulation in the rat brain membrane, and in 5-HT 2A -dependent contraction of isolated rat aorta rings and isolated guinea pig trachea. Cyamemazine antagonizes 5-HT 3 and 5-HT 2C receptors and that this effect is partially involved in its therapeutic activity in anxiety disorders. Acute administration of low doses of Cyamemazine can reduces extracellular dopamine and metabolite concentrations in rat striatum.