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3546-03-0

中文名稱 氰美馬嗪
英文名稱 cyamemazine
CAS 3546-03-0
分子式 C19H21N3S
分子量 323.46
MOL 文件 3546-03-0.mol
更新日期 2024/03/12 23:39:15
3546-03-0 結(jié)構(gòu)式 3546-03-0 結(jié)構(gòu)式

基本信息

中文別名
氰美馬嗪
賽馬咪嗪
賽馬咪嗪雜質(zhì)
氰美馬嗪雜質(zhì)
英文別名
TH-2602
RP-7204
Tercian
7204 RP
CiaMatil
Cianatil
CyaMeMazin
F. I. 6229
7204 R. E.
cyamemazine

物理化學(xué)性質(zhì)

熔點(diǎn)90-95°C
沸點(diǎn)bp0.2-0.5 205-220°
密度1.21±0.1 g/cm3(Predicted)
儲(chǔ)存條件Refrigerator
溶解度二甲基亞砜:≥5mg/mL
酸度系數(shù)(pKa)9.31±0.28(Predicted)
形態(tài)粉末
顏色淡黃色至黃綠色

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS09
警示詞警告
危險(xiǎn)性描述H410
防范說明P273-P501
危險(xiǎn)品標(biāo)志Xi,N
危險(xiǎn)類別碼50
安全說明61
危險(xiǎn)品運(yùn)輸編號(hào)UN 3077 9 / PGIII
WGK Germany3
毒性LDLo oral in man: 107mg/kg
氰美馬嗪價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-14264氰美馬嗪
Cyamemazine
3546-03-05mg800元
2024/11/08HY-14264氰美馬嗪
Cyamemazine
3546-03-010 mM * 1 mLin DMSO880元
2024/11/08HY-14264氰美馬嗪
Cyamemazine
3546-03-010mg1300元

常見問題列表

生物活性
Cyamemazine 是一種抗精神病藥,其中含有吩噻嗪發(fā)色團(tuán),通常被用作抗焦慮藥。Cyamemazine 是具有抗精神病活性的有效的 5-HT3 (Ki 為 12 nM), 5-HT2A (Ki 為 1.5 nM) 和 5-HT2C (Ki 為 75 nM) 受體拮抗劑。
靶點(diǎn)

5-HT 2A Receptor

1.5 nM (Ki)

5-HT 2C Receptor

12 nM (Ki)

5-HT 3 Receptor

75 nM (Ki)

體外研究

Cyamemazine exhibits a high affinity for dopamine receptors, which is consistent with its antipsychotic activity. The antagonist activity of Cyamemazine at muscarinic receptors is consistent with its affinity for M 1 ( K i = 13 nM), M 2 ( K i = 42 nM), M 3 ( K i = 321 nM), M 4 ( K i = 12 nM), and M 5 ( K i = 35 nM) receptors.

體內(nèi)研究

Cyamemazine behaves as an antagonist at the 5-HT 3 , 5-HT 2C , and 5-HT 2A receptors in 5-HT 3 -dependent contraction of isolated guinea pig ileum and bradycardic responses in rats, in 5-HT 2C -dependent phospholipase C stimulation in the rat brain membrane, and in 5-HT 2A -dependent contraction of isolated rat aorta rings and isolated guinea pig trachea. Cyamemazine antagonizes 5-HT 3 and 5-HT 2C receptors and that this effect is partially involved in its therapeutic activity in anxiety disorders. Acute administration of low doses of Cyamemazine can reduces extracellular dopamine and metabolite concentrations in rat striatum.

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