35286-58-9
中文名稱
苦丁冬青甙 H
英文名稱
3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
CAS
35286-58-9
分子式
C41H66O13
分子量
766.959
MOL 文件
35286-58-9.mol
更新日期
2024/11/05 14:04:21
35286-58-9 結構式
基本信息
中文別名
地榆皂苷I苦丁冬青苷H
地榆糖苷I)
苦丁冬青甙 H
苦丁冬青甙 I
地榆皂苷I對照品,
地榆皂苷I(標準品)
苦丁冬青苷H、苦丁冬青甙H
地榆皂苷I(苦丁冬青苷 H
苦丁冬青苷 H,苦丁冬青甙H,地榆糖苷I
英文別名
Gouguside 7Kudinoside H
Zigu-glucoside I
Ziyu-glycoside Ⅰ
Ulmus pumila saponin I
3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, β-D-glucopyranosyl ester, (3β)-
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate
所屬類別
天然產(chǎn)物：萜類物理化學性質
外觀性狀白色結晶體，可溶于甲醇、乙醇、DMSO等有機溶劑，來源于地榆。
熔點198-202 ºC
沸點841.9±65.0 °C(Predicted)
密度1.35
儲存條件-20°C, protect from light
溶解度Soluble in acetonitrile and methanol;
酸度系數(shù)(pKa)12.52±0.70(Predicted)
形態(tài)粉末
顏色白色
水溶解性不溶于水
常見問題列表
概述
地榆皂苷I，英文名ziyu-glycoside I，是從薔薇科地榆屬植物地榆或長葉地榆的根中提取得到的有明顯藥理活性的化合物。生物活性
Ziyuglycoside I 從 S. officinalis 根中分離，具有抗皺活性，并增加 I 型膠原蛋白的表達。 Ziyuglycoside I 可用作化妝品的有效成分。Ziyuglycoside I 引發(fā) p53 介導的細胞周期阻滯和凋亡 (apoptosis)，可用于三陰乳腺癌的相關研究。體外研究
Ziyuglycoside I (5-160 μM; 24 hours) reveals a marked anti-proliferation activity with an IC 50 value of 13.96 μM in MDA-MB-231 cells. Ziyuglycoside I (5-20 μM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 μM. Ziyuglycoside I (5-20 μM; 24 hours) induces the cleavage of caspas-8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression.
Cell Viability Assay
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 5 μM, 10 μM, 20 μM, 40 μM, 80 μM, and 160 μM |
| Incubation Time: | 24 hours |
| Result: | Showed cytotoxicity on MDA-MB-231 cells. |
Cell Cycle Analysis
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 5 μM, 10 μM, and 20 μM |
| Incubation Time: | 24 hours |
| Result: | Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells |
Western Blot Analysis
| Cell Line: | MDA-MB-231 cells |
| Concentration: | 5 μM, 10 μM, and 20 μM |
| Incubation Time: | 24 hours |
| Result: | Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways. |