| Identification | Back Directory | [Name]
3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester | [CAS]
35286-58-9 | [Synonyms]
Gouguside 7
Kudinoside H
Zigu-glucoside I
Ziyu-glycoside Ⅰ
Ulmus pumila saponin I
3-O-alpha-L-Arabinopyranosylpomolic acid beta-D-glucopyranosyl ester
Urs-12-en-28-oic acid, 3-(α-L-arabinopyranosyloxy)-19-hydroxy-, β-D-glucopyranosyl ester, (3β)-
[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-1-hydroxy-1,2,6a,6b,9,9,12a-heptamethyl-10-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylate | [EINECS(EC#)]
233-305-4 | [Molecular Formula]
C41H66O13 | [MDL Number]
MFCD13195536 | [MOL File]
35286-58-9.mol | [Molecular Weight]
766.959 |
| Chemical Properties | Back Directory | [Melting point ]
198-202 ºC | [Boiling point ]
841.9±65.0 °C(Predicted) | [density ]
1.35 | [storage temp. ]
-20°C, protect from light | [solubility ]
Soluble in acetonitrile and methanol; | [form ]
powder | [pka]
12.52±0.70(Predicted) | [color ]
White | [Water Solubility ]
insoluble in water |
| Hazard Information | Back Directory | [Chemical Properties]
White crystals, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Burnet. | [Uses]
Used for content determination/identification/pharmacological experiments, etc. | [Biological Activity]
Ziyuglycoside I, isolated from the roots of S. officinalis, has anti-wrinkle activity and increases collagen type I expression. It can be used as an active ingredient in cosmetics and induces p53-mediated cell cycle arrest and apoptosis (apoptosis), which can be used in the study of triple-negative breast cancer. | [Physiological effects]
Ziyuglycoside I has the functions of vasoconstriction, hemostasis and antifungal. | [in vitro]
Ziyuglycoside I (5-160 μM; 24 hours) reveals a marked anti-proliferation activity with an IC 50 value of 13.96 μM in MDA-MB-231 cells. Ziyuglycoside I ( 5-20 μM; 24 hours) induces MDA-MB-231 cell apoptosis by increasing the percentage of apoptotic cells from 2.43% to 44.76% at 20 μM. Ziyuglycoside I (5-20 μM; 24 hours) induces the cleavage of caspas- 8, caspase-9, and caspase-3, up-regulates the pro-apoptotic protein Bax, and down-regulates anti-apoptotic protein Bal-2, dose-dependently reduces the level of mito-cyto c expression. Cell Viability Assay | Cell Line: | MDA-MB-231 cells < /td> | | Concentration: | 5 μM, 10 μM, 20 μM, 40 μM, 80 μM, and 160 μM | | Incubation Time: | 24 hours | | Result: | Showed cytotoxicity on MDA-MB-231 cells. | Cell Cycle Analysis | Cell Line: | MDA-MB-231 cells | | Concentration: | 5 μM, 10 μM, and 20 μM | | Incubation Time: | 24 hours | | Result: | Induced G2/M phase arrest and apoptosis on MDA-MB-231 Cells | Western Blot Analysis | Cell Line: | MDA-MB-231 cells | | Concentration: | 5 μM, 10 μM, and 20 μM | | Incubation Time: | 24 hours | | Result: | Induced apoptosis in MDA-MB-231 Cells through Intrinsic and Extrinsic Pathways. | |
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