343-27-1
343-27-1 結(jié)構(gòu)式
基本信息
駱駝蓬堿鹽酸鹽
水合哈爾堿鹽酸鹽
鹽酸-7-甲氧基-1-甲基-9H-吡啶并(3,4-B)吲哚
鹽酸哈爾明
羅勒生物堿
7-METHOXY-1-METHYL-9H-PYRIDO[3,4-B]INDOLE HYDROCHLORIDE
BANISTERINE HYDROCHLORIDE
BANISTERIN HCL
HARMINE HCL
HARMINE HYDROCHLORIDE
4-b)indole,7-methoxy-1-methyl-9h-pyrido(monohydrochloride
harminemonohydrochloride
HARMINE HYDROCHLORIDE HYDRATE 98%
HARMINE HYDROCHLORID
CATHARANTHIN TARTRATE
DL-ANABASINE Hydrochloride
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
343-27-1(安全特性,毒性,儲運)
| 報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
| 2024/11/08 | S3817 | 哈爾堿鹽酸鹽(水合) Harmine hydrochloride | 343-27-1 | 25mg | 1777.43元 |
| 2024/11/08 | S3817 | Harmine hydrochloride | 343-27-1 | 10mM (1mL in DMSO) | 1875.51元 |
| 2024/11/08 | H0002 | 哈爾堿鹽酸鹽 Harmine Hydrochloride | 343-27-1 | 100MG | 190元 |
常見問題列表
| Target | Value |
|
DYRK1A
(Cell-free assay) | 33 nM |
|
MNB
(Cell-free assay) | 149 nM |
|
DYRK1B
(Cell-free assay) | 166 nM |
|
DYRK2
(Cell-free assay) | 1.9 μM |
Harmine inhibits tau phosphorylation by DYRK1A by selected DANDYs, with an IC 50 of 190 nM. Harmine negatively regulates homologous recombination (HR) by interfering Rad51 recruitment, resulting in severe cytotoxicity in hepatoma cells. Furthermore, NHEJ inhibitor Nu7441 markedly sensitizes Hep3B cells to the anti-proliferative effects of Harmine.
It is shown that brain water content is significantly increased in the TBI group. Treatment with Harmine significantly reduces the tissue water content at 1, 3 and 5 days, compared with the TBI group. Harmine treatment significantly reduces the escape latency at 3 and 5 days, compared with the TBI group. Post-TBI administration of Harmine significantly improves the motor function recovery of the rats at 1, 3 and 5 days following TBI, compared with the TBI group without Harmine treatment. The neuronal survival rate in the Harmine-treated group is significantly increased, compared with the TBI group. Administration of Harmine results in marked elevation in the expression of GLT-1, compared with the TBI group. The administration of Harmine significantly reduces the expression of caspase 3, compared with the TBI group.