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341028-37-3

中文名稱 4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物
英文名稱 Alagebrium chloride
CAS 341028-37-3
分子式 C13H14ClNOS
MDL 編號(hào) MFCD09027398
分子量 267.77
MOL 文件 341028-37-3.mol
更新日期 2024/12/23 09:09:20
341028-37-3 結(jié)構(gòu)式 341028-37-3 結(jié)構(gòu)式

基本信息

中文別名
4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑鎓氯化物
4,5-二甲基-3-(2-氧代-2-苯乙基)-噻唑氯化物
4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物
英文別名
2-(4,5-dimethyl-1,3-thiazol-3-yl)-1-phenyl-ethanone chloride
4,5-dimethyl-3-(2-oxo-2-phenylethyl)thiazolium chloride
alagebrium chloride
ALT-711
Dimethyl-3-(2-oxo-2-phenyl)-chloride
(Alagebrium) (thiazolium salt)
所屬類別
有機(jī)原料:雜環(huán)化合物

物理化學(xué)性質(zhì)

熔點(diǎn)212 °C(dec.)
儲(chǔ)存條件Hygroscopic, Refrigerator, under inert atmosphere
溶解度可溶于DMSO(少許)、甲醇(少許)
形態(tài)固體
顏色白色至灰白色
Merck14,203
CAS 數(shù)據(jù)庫341028-37-3(CAS DataBase Reference)

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS05
警示詞危險(xiǎn)
危險(xiǎn)性描述H318-H315-H302-H335
海關(guān)編碼2934.99.4400
4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/11/08HY-106024B4,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物
Alagebrium chloride
341028-37-3200mg500元
2024/11/08XW02341028373044,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物341028-37-35G1382元
2024/11/08XW02341028373034,5-二甲基-3-(2-氧代-2-苯基乙基)噻唑氯化物341028-37-31G299元

常見問題列表

生物活性
Alagebrium chloride 是一種晚期糖基化終產(chǎn)物 (AGE) 抑制劑。
靶點(diǎn)

AGE

體外研究

Alagebrium chloride is an advanced glycation end product ( AGE ) inhibitor. Endothelial cell (EC) proliferation is increased for all groups receiving Alagebrium (ALT-711), particularly when seeded on matrix from the AAo of obese (ZO) and diabetic (ZD) rats.

體內(nèi)研究

Blood pressure is not affected by treatment with Alagebrium. In diabetic RAGE apoE double-KO mice, treatment with Alagebrium is associated with a modest reduction in renal mass and reduces hyperfiltration compare with nontreated mice. Treatment with Alagebrium in diabetic RAGE apoE double-KO mice is associated with a further reduction in glomerular collagen IV levels, approaching levels observed in control mice. Body weight, heart rate (HR), and mean blood pressure (BP) are similar in Zucker lean (ZL), obese (ZO), and diabetic (ZD) groups in the absence or presence of Alagebrium (ALT-711). Alagebrium increases blood flow (BF) in ZO rats but reduces distal vascular resistance in ZD rats. A decrease in neointimal hyperplasia (NH) intrastrut thickness as a function of local radius is found in all groups with Alagebrium treatment. A significant increase in TGF-β expression is also found in the AAo of ZL rats treated with Alagebrium.

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