25614-03-3
中文名稱
溴隱亭
英文名稱
Bromocriptine
CAS
25614-03-3
EINECS 編號(hào)
247-128-5
分子式
C32H40BrN5O5
MDL 編號(hào)
MFCD00870213
分子量
654.59
MOL 文件
25614-03-3.mol
更新日期
2024/07/28 20:25:14
25614-03-3 結(jié)構(gòu)式
基本信息
中文別名
溴麥角環(huán)肽溴麥角隱亭
溴麥亭
溴隱亭
溴代麥角隱亭堿
溴隱亭(2-溴-ALPHA-麥角環(huán)肽)
2-溴-ALPHA-麥角環(huán)肽
2-溴-12'-羥基-5'-ALPHA-異丁基-2'-異丙基麥角胺-3',6',18-三酮
英文別名
BROMOCRIPTINE(5’-alpha)-ropyl)
,6’,18-trione
2-bromo-12’-hydroxy-2’-(1-methylethyl)-5’-alpha-(2-methylpropyl)ergotamin-3’
2-bromo-alpha-ergocryptine
2-bromo-alpha-ergokryptin
2-bromo-alpha-ergokryptine
2-bromo-ergocryptin
2-bromoergocryptine
alpha-bromoergocriptine
bromergocryptine
bromocriptin
bromocryptine
bromoergocriptine
bromoergocryptine
ergotaman-3’,6’,18-trione,2-bromo-12’-hydroxy-2’-(1-methylethyl)-5’-(2-methylp
(5'alpha)-2-bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione
Kripton
Parlodel
Bromoergocryptine mesylate
物理化學(xué)性質(zhì)
外觀性狀白色結(jié)晶性粉末。熔點(diǎn)215-218℃（分解）。
熔點(diǎn)215-218° (dec)
比旋光度D20 -195° (c = 1 in methylene chloride)
沸點(diǎn)891.3±65.0 °C(Predicted)
密度1.2734 (rough estimate)
折射率1.6400 (estimate)
酸度系數(shù)(pKa)pKa 4.90±0.05(80% MCS
t = RT) (Uncertain)
水溶解性2.07mg/L(temperature not stated)
CAS 數(shù)據(jù)庫25614-03-3(CAS DataBase Reference)
安全數(shù)據(jù)
警示詞警告
危險(xiǎn)性描述H361-H362-H302
防范說明P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P312-P330-P501-P201-P260-P263-P264-P270-P308+P313
毒性An ergot alkaloid
derivative that exhibits potent dopamine agonist properties, particularly
at D2 dopamine receptors. Bromocriptine, like dopamine,
inhibits prolactin release from the pituitary and so is used in endocrine
disorders, such as hyperprolactinemia. It is also used in the
treatment of Parkinson’s disease. A large “first-pass” effect is seen
with bromocriptine, and peak concentrations occur about 1.5-3 h
after ingestion, with a half-life of about 3 h. Nausea, vomiting, and
orthostatic hypotension are among the acute adverse effects.
Long-term use has been associated with dyskinesias, constipation,
psychoses, digital spasm, and erythromelalgia. The LD50 in rabbits
exceeds 1 g/kg, p.o., and 12 mg/kg, i.v.
應(yīng)用領(lǐng)域
用途一
該品具有多巴胺受體的興奮作用?？赏高^血腦屏障，進(jìn)入中樞神經(jīng)內(nèi)，激動(dòng)多巴胺受體和抑制催乳素及生長激素分泌作用。臨床用于帕金森氏癥、肢端肥大癥和乳溢癥等。