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24735-18-0

中文名稱 益母草堿單鹽酸鹽
CAS 24735-18-0
分子式 C14H22ClN3O5
分子量 347.795
MOL 文件 24735-18-0.mol
更新日期 2024/10/25 15:17:18
24735-18-0 結(jié)構(gòu)式 24735-18-0 結(jié)構(gòu)式

基本信息

中文別名
益母草堿單鹽酸鹽
鹽酸益母草堿(益母草堿鹽酸鹽)
英文別名
SCM-198 HCl
SCM-198 hydrochloride
Leonurin monohydrochloride
4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride
4-Hydroxy-3,5-dimethoxybenzoic acid 4-[(aminoiminomethyl)amino]butyl ester monohydrochloride

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶粉末,易溶于甲醇、水,來源于益母草Leonurus artemisia (Laur.) S. Y. Hu F。
熔點(diǎn)194℃
儲(chǔ)存條件Sealed in dry,Room Temperature

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS06
警示詞危險(xiǎn)
危險(xiǎn)性描述H301+H311+H331

應(yīng)用領(lǐng)域

用途1
鹽酸益母草堿具有活血、祛淤、調(diào)經(jīng)、消水的作用。
益母草堿單鹽酸鹽價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2024/08/19S9047益母草堿單鹽酸鹽
Leonurine Hydrochloride
24735-18-05mg1204.75元
2023/03/20S9047益母草堿單鹽酸鹽
Leonurine Hydrochloride
24735-18-025mg3849.55元

常見問題列表

生物活性
Leonurine hydrochloride 是從 Herba leonuri 中分離到的生物堿,具有抗氧化、抗炎活性。
體外研究

Leonurine (0, 5, 10, 20, 40, 80 μM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24?h. Leonurine hydrochloride (125, 250, 500?μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20?μM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner.

體內(nèi)研究

Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20?mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model.

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