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2390-54-7

中文名稱 硫黃素 T
英文名稱 Thioflavine T
CAS 2390-54-7
EINECS 編號 219-228-9
分子式 C17H19ClN2S
MDL 編號 MFCD00011944
分子量 318.86
MOL 文件 2390-54-7.mol
更新日期 2024/12/16 14:31:24
2390-54-7 結(jié)構(gòu)式 2390-54-7 結(jié)構(gòu)式

基本信息

中文別名
氯化2-[4-(二甲氨基)苯基]-3,6-二甲基苯并噻唑翁
堿性黃1
硫代磺素T
硫代黃色素 T
硫黃素 T
鹽基嫩黃
硫代磺素T/堿性黃1
2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑鎓氯化物
2-[4-(二甲基氨基)苯基]-3,6-二甲基苯并噻唑氯化物
硫磺素T/堿性黃1
英文別名
BASIC YELLOW 1
CI 49005
CI NO 49005
LABOTEST-BB LT00451909
SETOFLAVINE T
THIOFLAVINE T
THIOFLAVINE TG
THIOFLAVINE T, TCN, TG
THIOFLAVIN T
THT
2-[4-(dimethylamino)phenyl]-3,6-dimethyl-benzothiazoliuchloride
Benzothiazolium,2-[4-(dimethylamino)phenyl]-3,6-dimethyl-,chloride
2-[4-(dimethylamino)phenyl]-3,6-dimethylbenzothiazolium chloride
THIOFLAVINE T, FOR MICROSCOPY
ThioflavineTC.I.49005
THIOFLAVINET,TG
Basic yellow 1 (C.I. 49005)
C.I. Basic Yellow 1
Basic Yellow1, Thioflavine T
4-(3,6-Dimethyl-1,3-benzothiazol-3-ium-2-yl)-N,N-dimethylaniline chloride
所屬類別
生物化工:生物染料

物理化學性質(zhì)

熔點211-212 °C (decomp)
密度1.301g/cm3 at 20℃
蒸氣壓0Pa at 25℃
儲存條件Store below +30°C.
溶解度在甲醇中可溶1mg/mL
色指數(shù)49005
形態(tài)粉末
顏色黃色至黃褐色
BRN3922452
InChIInChI=1S/C17H19N2S.ClH/c1-12-5-10-15-16(11-12)20-17(19(15)4)13-6-8-14(9-7-13)18(2)3;/h5-11H,1-4H3;1H/q+1;/p-1
InChIKeyJADVWWSKYZXRGX-UHFFFAOYSA-M
SMILESC1(=[N+](C)C2C=CC(C)=CC=2S1)C1C=CC(N(C)C)=CC=1.[Cl-]
LogP3.02 at 25℃ and pH7.98
CAS 數(shù)據(jù)庫2390-54-7(CAS DataBase Reference)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
安全說明24/25
安全說明S24/25
危險品運輸編號2811
WGK Germany3
WGK Germany3
TSCAYes
危險等級6.1(b)
包裝類別III
海關編碼32041300

應用領域

用途1
一種苯并噻唑染料,在與淀粉體連接時可提高熒光效率;用于組織學以及蛋白質(zhì)表征中

化學品安全說明書(MSDS)

知名試劑公司產(chǎn)品信息

硫黃素 T價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/11/0821176硫黃素 T
Thioflavin T, Thermo Scientific Chemicals
2390-54-75g556元
2024/11/0821176硫黃素 T
Thioflavin T, Thermo Scientific Chemicals
2390-54-725g1233元
2024/11/0821176硫黃素 T
Thioflavin T, Thermo Scientific Chemicals
2390-54-7100g4375元

常見問題列表

生物活性
Thioflavin T (ThT, Basic Yellow 1) 是一種苯并噻唑染料,與淀粉樣蛋白原纖維結(jié)合后顯示增強的熒光,通常用于診斷淀粉樣蛋白原纖維。
體外研究

Thioflavin T (ThT) is a benzothiazole dye that exhibits enhanced fluorescence upon binding to amyloid fibrils and is commonly used to diagnose amyloid fibrils, both ex vivo and in vitro. In aqueous solutions, Thioflavin T is found to exist as micelles at concentrations commonly used to monitor fibrils by fluorescence assay (~10-20 μM). Specific conductivity changes are measured at varying concentration of Thioflavin T and the critical micellar concentration is calculated to be 4.0±0.5 μM. Changes in the fluorescence excitation and emission of Thioflavin T are also dependent on the micelle formation. The Thioflavin T micelles of 3 nm diameter are directly visualized using atomic force microscopy, and bound Thioflavin T micelles are observed along the fibril length for representative fibrils. Increasing concentration of Thioflavin T above the critical micellar concentration shows increased numbers of micelles bound along the length of the amyloid fibrils. Thioflavin T micelles are disrupted at low pH as observed by atomic force microscopy and fluorescence enhancement upon binding of Thioflavin T to amyloid fibrils also reduced by several-fold upon decreasing the pH to below 3.The micelles of Thioflavin T bind amyloid fibrils leading to enhancement of fluorescence emission.

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