1852-38-6
基本信息
未標(biāo)記的孕烯醇硫酸鹽
孕烯醇硫酸鹽 (20,21-13C2,99%
PREGNENOLONE SULFATE SODIUM
SodiuM Pregnenolone-d4 Sulfate
5-Pregnen-3β-ol-20-one sulfate
Pregnenolone sulphate Na+ salt
PREGNENOLONE SULFATE SODIUM SALT
PREGNENOLONE SULPHATE, SODIUM SALT
Pregnenolone-3-sulfate SodiuM Salt
3-Hydroxypregn-5-en-20-one sulfate
Pregnenolone monosulfate sodium salt
物理化學(xué)性質(zhì)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/11/08 | HY-110189 | PREGNENOLONE MONOSULFATE SODIUM SALT Pregnenolone monosulfate sodium salt | 1852-38-6 | 5mg | 550元 |
2024/11/08 | HY-110189 | PREGNENOLONE MONOSULFATE SODIUM SALT Pregnenolone monosulfate sodium salt | 1852-38-6 | 10mg | 880元 |
2024/11/08 | HY-110189 | PREGNENOLONE MONOSULFATE SODIUM SALT Pregnenolone monosulfate sodium salt | 1852-38-6 | 50mg | 1850元 |
常見問題列表
CB1
|
Human Endogenous Metabolite
|
CB1 receptor stimulation increases brain Pregnenolone levels, which in turn exerts a negative feedback on the activity of the CB1 receptor antagonizing most of the known behavioral and somatic effects of THC. Pregnenolone likely acts as a signaling-specific negative allosteric modulator binding to a site distinct from that occupied by orthosteric ligands. Pregnenolone does not modify agonist binding but only agonist efficacy.
The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC).
Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se . Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule.