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16858-02-9

中文名稱 N,N,N',N'-四(2-吡啶甲基)乙二胺
英文名稱 TPEN
CAS 16858-02-9
分子式 C26H28N6
MDL 編號 MFCD00036918
分子量 424.54
MOL 文件 16858-02-9.mol
更新日期 2024/12/19 17:28:37
16858-02-9 結構式 16858-02-9 結構式

基本信息

中文別名
TPEN
英文別名
N,N,N',N'-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE
TETRAKIS-(2-PYRIDYLMETHYL)ETHYLENEDIAMINE
TPEN
N,N,N',N',-TETRAKIS(2-PYRIDYLMETHYL)*ETH YLENEDIAMIN
TPEN/CH63857
N,N,NNTetrakis(2-pyridylmethyl)-1,2-ethylenediamine
N,N,NNTetrakis-pyridin-2-ylmethyl-ethane-1,2-diamine
N,N,N'',N''-TETRAKIS(2-PYRIDYLMETHYL)ETHYLENEDIAMINE (TPEN)
N,N,N'',N''-Tetrakis-(2-pyridylmethyl)-ethylenediame
N,N,N',N'-Tetra(2-pyridyl)-1,2-ethanediamine
N,N'-Ethylenebis[bis(2-pyridyl)amine]
所屬類別
醫(yī)藥中間體:吡啶衍生物

物理化學性質

熔點110-112 °C
熔點110-112 °C
沸點530.56°C (rough estimate)
密度1.3893 (rough estimate)
折射率1.4570 (estimate)
儲存條件Sealed in dry,2-8°C
溶解度溶于DMSO(高達10mg/ml)。
酸度系數(pKa)5.19±0.12(Predicted)
形態(tài)棕褐色固體
顏色灰白色或棕褐色
BRN4211982
穩(wěn)定性可在-20°C下的DMSO中的溶液儲存長達3個月。

安全數據

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H319-H335
危險品標志Xi
危險類別碼36/37/38
危險類別碼R36/37/38
安全說明26-36
安全說明S26-S36
WGK Germany3
WGK Germany3
海關編碼29333990

知名試劑公司產品信息

TCI Shanghai
N,N,N',N'-四(2-吡啶甲基)乙二胺價格(試劑級)
報價日期產品編號產品名稱CAS號包裝價格
2024/11/08J64206N,N,N',N'-四kis-(2-吡啶基甲基)乙二胺
N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine
16858-02-9100mg1862元
2024/11/08J64206N,N,N',N'-四kis-(2-吡啶基甲基)乙二胺
N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine
16858-02-9300mg4657元
2024/11/08HY-100202N,N,N',N'-四(2-吡啶甲基)乙二胺
TPEN
16858-02-950mg550元

常見問題列表

生物活性
TPEN (TPEDA) 是一種可透過細胞的重金屬螯合劑,可通過負調控細胞內 NO 和 Zn2+ 信號轉導來誘導NB4細胞凋亡。TPEN(TPEDA)可能是APL (acute promyelocytic leukemia) 的潛在治療策略之一。
靶點
TargetValue
NO
()
體外研究

Heavy metal chelator TPEN attenuates fura-2 fluorescence changes induced by cadmium, mercury and methylmercury. TPEN, a cell-permeable chelator for heavy metal cations with a low affinity for Ca 2+ . In cells stimulated with 10 or 30 μM cadmium chloride, the addition of TPEN at 3 hr after exposure significantly decreases the elevated fura-2 fluorescence ratio to the basal levels within 10 min (119.6±2.4% or 109±1.5% decrease in ΔRatio (F340/F380) induced by 10 or 30 μM cadmium chloride, respectively), suggesting that a cadmium chloride-induced increase in the fura-2 fluorescence ratio is dependent on an increase in intracellular heavy metal cations but not intracellular Ca 2+ . TPEN is a metal chelator, which targets colon cancer cells through redox cycling of copper. TPEN reduces cell viability in a dose- and time-dependent manner. TPEN-induced cell death is also dependent on the redox cycling of copper since the copper chelator neocuproine inhibited DNA damage and reduced pChk1, γ-H2AX, and ATM protein expression. Cell death by low TPEN concentrations, involved ATM/ATR signaling in all 3 cell lines, since pre-incubation with specific inhibitors of ATM and DNA-PK led to the recovery of cells from TPEN-induced DNA damage.

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