1421227-52-2
中文名稱
重復(fù)
英文名稱
WS3
CAS
1421227-52-2
分子式
C28H30F3N7O3
分子量
569.58
MOL 文件
1421227-52-2.mol
更新日期
2024/12/23 09:08:07
1421227-52-2 結(jié)構(gòu)式
基本信息
中文別名
重復(fù) 英文別名
CS-1800WS-3
WS 3
WS3, >=98%
WS3 USP/EP/BP
WS3, 1421227-52-2
N-(6-(4-(3-(4-((4-METHYLPIPERAZIN-1-YL)METHYL)-3-(TRIFLUOROMETHYL)PHENYL)UREIDO)PHENOXY)PYRIMIDIN-4-YL)CYCLOPROPANECARBOXAMIDE
N-(6-{4-[({4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}carbamoyl)amino]phenoxy}pyrimidin-4-yl)cyclopropanecarboxamide
N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide
Cyclopropanecarboxamide, N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-
N-[6-[4-[[[[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-4-pyrimidinyl]-cyclopropanecarboxamide WS3
所屬類別
生物化工：IκB/IKK 抑制劑物理化學(xué)性質(zhì)
沸點(diǎn)632.9±55.0 °C(Predicted)
密度1.423±0.06 g/cm3(Predicted)
儲存條件Sealed in dry,2-8°C
溶解度DMSO：可溶10mg/mL，澄清
酸度系數(shù)(pKa)11.82±0.20(Predicted)
形態(tài)粉末
顏色白色至米色
常見問題列表
生物活性
WS3 是一種的增殖分子，可促進(jìn)鼠和人原代胰島的胰腺 β 細(xì)胞增殖 (β cell proliferation)。WS3 可用于 I 型糖尿病的研究。靶點(diǎn)
IC50: 0.28 μM (β cell proliferation)
體外研究
WS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC 50 value of 0.28 μM.WS3 (1.0 nM-1.0 μM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments.