14173-40-1
中文名稱
4-氯-DL-苯丙氨酸甲酯鹽酸鹽
英文名稱
DL-4-Chlorophenylalanine methyl ester hydrochloride
CAS
14173-40-1
EINECS 編號(hào)
238-024-0
分子式
C10H13Cl2NO2
MDL 編號(hào)
MFCD00012530
分子量
250.12
MOL 文件
14173-40-1.mol
更新日期
2024/09/09 16:21:13
14173-40-1 結(jié)構(gòu)式
基本信息
中文別名
4-氯-DL-苯丙氨酸甲酯鹽酸鹽DL-4-氯苯丙氨酸甲酯鹽酸鹽
鹽酸-DL-4-氯苯丙氨酸甲酯
英文別名
4-CHLORO-DL-PHENYLALANINE METHYL ESTER HCL4-CHLORO-DL-PHENYLALANINE METHYL ESTER HYDROCHLORIDE
4-CHLORO-DL-PHE-OME HCL
DL-4-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
DL-P-CHLOROPHENYLALANINE METHYL ESTER HYDROCHLORIDE
H-DL-PHE(4-CL)-OME HCL
H-P-CHLORO-DL-PHE-OME HCL
Methyl 4-chloro-3-phenyl-DL-alaninate hydrochloride
P-CHLORO-DL-PHENYLALANINE HCL
P-CHLORO-DL-PHENYLALANINE METHYL ESTER HYDROCHLORIDE
TIMTEC-BB SBB003149
3-(p-chlorophenyl)-,methylester,hydrochloride,dl-alanin
dl-3-(p-chlorophenyl)alaninemethylesterhydrochloride
dl-pcpamethylesterhydrochloride
dl-phenylalanine,4-chloro-,methylester,hydrochloride
DL-P-CHLOROPHENYLALANINE METHYL ESTER*HY
4-Chloro-Dl-PhenylalanineMethylEster
4-Chloro-DL-Phe-OMe•
4-CHLORO-DL-PHENYLALANINE METHYLESTER HCI
(±)-4-Chlorophenylalanine methyl
所屬類別
生物化工：苯丙氨酸類衍生物物理化學(xué)性質(zhì)
熔點(diǎn)186-189 °C(lit.)
熔點(diǎn)186-189 °C(lit.)
儲(chǔ)存條件−20°C
儲(chǔ)存條件-20°C
溶解度Soluble to 100 mM in water and to 100 mM in DMSO
形態(tài)固體
顏色White to off-white
CAS 數(shù)據(jù)庫14173-40-1(CAS DataBase Reference)
安全數(shù)據(jù)
4-氯-DL-苯丙氨酸甲酯鹽酸鹽價(jià)格(試劑級(jí))
| 報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
| 2024/08/19 | HY-101456 | 4-氯-DL-苯丙氨酸甲酯鹽酸鹽 PCPA methyl ester hydrochloride | 14173-40-1 | 1 g | 800元 |
| 2024/04/30 | H63260 | 4-氯-DL-苯丙氨酸甲酯鹽酸鹽 4-Chloro-DL-phenylalanine methyl ester hydrochloride, 98% | 14173-40-1 | 1g | 384元 |
| 2024/04/30 | H63260 | 4-氯-DL-苯丙氨酸甲酯鹽酸鹽 4-Chloro-DL-phenylalanine methyl ester hydrochloride, 98% | 14173-40-1 | 5g | 2739元 |
常見問題列表
生物活性
PCPA methyl ester hydrochloride (4-Chloro-DL-phenylalanine methyl ester hydrochloride) 是一種可逆的色氨酸羥化酶 (tryptophan hydroxylase) 抑制劑，是 5-羥色胺 (5-HT) 合成抑制劑。PCPA methyl ester hydrochloride 可穿過血腦屏障，并降低 5-HT 的中樞利用率。靶點(diǎn)
|
serotonin
|
Tryptophan Hydroxylase
|
體內(nèi)研究
PCPA methyl ester hydrochloride (250-500 mg/kg; oral administration; daily; for 8 weeks) treatment significantly decreases serotonin levels in both hippocampus and cortex.
In C57BL/6 elite male mice, 5-HT levels decreased by 85% and 55% in the hippocampus of mice treated with oral or ip PCPA methyl ester hydrochloride, respectively, whereas in the prefrontal cortex, 5-HT levels decreased by 65% (oral) and 50% (ip).
| Animal Model: | C57BL/6 elite male mice (3 months old) |
| Dosage: | 500 mg/kg per day for the first 2 days and 250 mg/kg for the rest of the treatment |
| Administration: | Oral administration; daily; for 8 weeks |
| Result: | Serotonin levels were significantly decreased in both hippocampus and cortex. |