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138356-21-5

中文名稱 BD-1047鹽酸鹽
英文名稱 BD 1047 dihydrobromide
CAS 138356-21-5
分子式 C13H22Br2Cl2N2
分子量 437.041
MOL 文件 138356-21-5.mol
更新日期 2024/10/25 11:17:08
138356-21-5 結(jié)構(gòu)式 138356-21-5 結(jié)構(gòu)式

基本信息

中文別名
N-[2-(3,4-二氯苯基)乙基]-N,N',N'-三甲基-1,2-乙二胺二氫溴酸鹽
英文別名
169592
BD1047.2HBr
BD 1047 HBr
BD-1047
BD 1047
BD1047.2HBr(1K/g)
BD 1047 (hydrobromide)
N1-(3,4-DICHLOROPHENETHYL)-N1,N2,N2-TRIMETHYLETHANE-1,2-DIAMINE 2HBR
N1-(3,4-dichlorophenethyl)-N1,N2,N2-trimethylethane-1,2-diamine dihydrobromide
N-[2-(3,4-Dichlorophenyl)ethyl]-N,N',N'-trimethyl-1,2-ethanediamine dihydrobromide
n-[2-(3,4-dichlorophenyl)ethyl]-n,n',n'-trimethylethane-1,2-diamine dihydrobromide
所屬類別
生物化工:激動劑抑制劑

物理化學(xué)性質(zhì)

儲存條件Inert atmosphere,2-8°C
溶解度在水中的溶解度>5mg/mL
形態(tài)粉末
顏色白色
穩(wěn)定性Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictogramsGHS hazard pictograms
GHS05,GHS07
警示詞危險
危險性描述H315-H318-H335
危險品標(biāo)志Xi
危險類別碼37/38-41
安全說明26-36/37
WGK Germany3
BD-1047鹽酸鹽價格(試劑級)
報價日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價格
2024/08/19S0106BD-1047鹽酸鹽
BD-1047 dihydrobromide
138356-21-55mg753.46元
2024/08/19S0106BD-1047鹽酸鹽
BD-1047 dihydrobromide
138356-21-525mg2024.47元

常見問題列表

生物活性
BD-1047 dihydrobromide (HBr) 是一種 sigma-1 (σ1) receptor 的選擇性的功能拮抗劑,在動物模型中顯示出抗精神病活性,可預(yù)測對精神分裂癥的療效。
靶點
TargetValue
σ1 receptor
()
體外研究

BD-1047 (dihydrobromide) prevents that Cutamesine reduces the cell death rate induced by light exposure in murine photoreceptor-derived 661w cells.
BD-1047 (dihydrobromide) attenuates that Cutamesine reduces the mitochondrial damage and the elevated level of caspase 3/7 activity.

體內(nèi)研究

BD-1047 (dihydrobromide) (1-10 mg/kg; i.p.) decreases the Apomorphine (APO)-induced climbing behavior at the dose of 10 mg/kg in mice.
BD-1047 (dihydrobromide) counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline (but not pramipexole and fluoxetine).
BD-1047 (dihydrobromide) reduces the increasing expression of pNR1, and reverses the Sig-1 R agonists potentiated NMDA-induced pain behaviour and pNR1 immunoreactivity.

Animal Model: Male Albino Swiss mice (50 days old, 25–28 g)
Dosage: 1 mg/kg, 3 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection
Result: Decreased the APO-induced climbing at the dose of 10 mg/kg in mice.
"138356-21-5" 相關(guān)產(chǎn)品信息
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