129-20-4
中文名稱
羥保松
英文名稱
OXYPHENYL BUTAZONE
CAS
129-20-4
EINECS 編號
204-936-2
分子式
C19H20N2O3
MDL 編號
MFCD00057278
分子量
324.37
MOL 文件
129-20-4.mol
129-20-4 結(jié)構(gòu)式
基本信息
中文別名
羥保松羥布宗
羥基保泰松
羥基保泰松,坦特利爾,羥保松
英文別名
LABOTEST-BB LT00134684OXYPHENYL BUTAZONE
1-(p-Hydroxyphenyl)-2-phenyl-3,5-dioxo-4-N-butylpyrazolidine
1-(p-Hydroxyphenyl)-2-phenyl-4-butyl-3,5-pyrazolidinedione
1-(p-hydroxyphenyl)-2-phenyl-4-butylpyrazolidine-3,5-dione
1-Phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-butylpyrazolidine
1-phenyl-2-(p-hydroxyphenyl)-3,5-dioxo-4-n-butylpyrazolidine
1-p-hydroxyphenyl-2-phenyl-3,5-dioxo-4-n-butylpyrazolidine
3,5-Dioxo-1-phenyl-2-(p-hydroxyphenyl)-4-N-butylpyrazolidene
3,5-Pyrazolidinedione, 4-butyl-1-(4-hydroxyphenyl)-2-phenyl-
3,5-Pyrazolidinedione, 4-butyl-1-(p-hydroxyphenyl)-2-phenyl-
3,5-pyrazolidinedione,4-butyl-1-(4-hydroxyphenyl)-2-phenyl
4-Butyl-1-(4-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
4-Butyl-1-(p-hydroxyphenyl)-2-phenyl-3,5-pyrazolidinedione
4-butyl-1-(p-hydroxyphenyl)-2-phenyl-5-pyrazolidinedione
4-Butyl-2-(4-hydroxyphenyl)-1-phenyl-3,5-dioxopyrazolidine
4-Butyl-2-(p-hydroxyphenyl)-1-phenyl-3,5-pyrazolidinedione
Artroflog
BM 1
bm1
所屬類別
原料藥：非甾抗炎藥物理化學(xué)性質(zhì)
外觀性狀白色結(jié)晶或結(jié)晶性粉末。熔點124-125℃。易溶于乙醇、丙酮，溶于氯仿、苯、醚，不溶于水。易溶于氫氧化碳或碳酸堿溶液。無臭，味苦。
熔點109-111°C
沸點462.71°C (rough estimate)
密度1.2118 (rough estimate)
折射率1.6140 (estimate)
儲存條件-20°C
溶解度DMSO：可溶10mg/mL，澄清
酸度系數(shù)(pKa)pKa 4.7/10.0±0.2(H2O,t =25,Iundefined) (Uncertain)
形態(tài)粉末
顏色白色至棕色
水溶解性20mg/L(room temperature)
穩(wěn)定性吸濕性
CAS 數(shù)據(jù)庫129-20-4(CAS DataBase Reference)
(IARC)致癌物分類3 (Vol. 13, Sup 7) 1987
EPA化學(xué)物質(zhì)信息3,5-Pyrazolidinedione, 4-butyl-1-(4-hydroxyphenyl)-2-phenyl- (129-20-4)
安全數(shù)據(jù)
警示詞警告
危險性描述H302-H400
危險品標(biāo)志Xn,N
危險類別碼22-50
安全說明61
危險品運輸編號UN 3077 9 / PGIII
WGK Germany3
毒害物質(zhì)數(shù)據(jù)129-20-4(Hazardous Substances Data)
應(yīng)用領(lǐng)域
用途一
用于治療痛風(fēng)、關(guān)節(jié)炎、風(fēng)濕性或類風(fēng)濕性關(guān)節(jié)炎及關(guān)節(jié)強硬性脊椎炎等。常見問題列表
生物活性
Oxyphenbutazone 是一種苯丁酮衍生物，具有抗炎作用。Oxyphenbutazone 是一種非選擇性的 COX 抑制劑。Oxyphenbutazone 能選擇性地殺死不復(fù)制的結(jié)核分枝桿菌。靶點
COX
體外研究
Oxyphenbutazone enhances the anticancer efficiency of methotrexate (MTX) in Hep3B cells.
Oxyphenbutazone (2.5 -7.5 μM; 48 hours) co-treatment with (MTX, 0.25-1.0 μM) shows potential cytotoxicity against Hep3B cells.
Oxyphenbutazone exhibits reparative effects in the hepatocytes.
Cell Cytotoxicity Assay
| Cell Line: | Hep3B cells |
| Concentration: | 2.5 μM, 5 μM, 7.5 μM |
| Incubation Time: | 48 hours |
| Result: | Enhanced the cytotoxicity of MTX. |
體內(nèi)研究
Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.).
| Animal Model: | 5–6 weeks Wistar strain albino male rats (150–220 g) |
| Dosage: | 70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week) |
| Administration: | Oral administration; once a week; in two divided doses; for 13 weeks |
| Result: | Exerted potential anticancer activity in rats when co-treatment with MTX. |