121584-18-7
基本信息
伐司撲達
伐司樸達
P-糖蛋白抑制劑(VALSPODAR)
AMdray
Psc 833
Valpodar
Valspodar
Sdz-psc-833
Sdz psc 833
Valspodar, >=98%
PSC833(Valspodar)
Valspodar (PSC-833)
物理化學性質(zhì)
報價日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
2024/08/19 | HY-17384 | 伐司撲達 Valspodar | 121584-18-7 | 1mg | 3500元 |
2023/03/20 | HY-17384 | 伐司撲達 Valspodar | 121584-18-7 | 5mg | 11200元 |
2022/09/18 | HY-17384 | 伐司撲達 Valspodar | 121584-18-7 | 10 mg | 8650元 |
常見問題列表
Valspodar (PSC 833) has no cytotoxicity effects at up to the concentration of 0.75 μg/mL. Valspodar (0.25, 0.5 and 0.75 μg/mL) and DOX-L are added to the DOX resistant cells, and cell kill efficacy of MDR cell type increases significantly when valspodar is administered alongside DOX-L. Valspodar (0.5 and 0.75 μg/mL), in combination with all concentrations of DOX, are most toxic and kill more than 70% of the resistant cells. Pretreatment with PSC833 decreases the IC 50 value of NSC 279836 in MDA-MB-435mdr cells to 0.4±0.02 μM in MDR cells and almost completely reverses the resistance of MDR cells to NSC 279836.
valspodar (10 mg/kg, o.p.) exhibits minimal blood-cell partitioning as reflected in its low mean blood-to-plasma ratio of approximately 0.52. Valspodar displays properties of slow clearance and a large volume of distribution. Valspodar shows properties of low hepatic extraction and wide distribution, similar to that of its structural analogue CsA. Preadministration of PSC833 to mice increases NSC 279836 fluorescent intensity in MDR tumor to 94% of that in the wild-type tumors.