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115074-43-6

中文名稱 莫匹羅星鈣(二水合物)
英文名稱 MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD
CAS 115074-43-6
分子式 C52H86CaO18.2H2O
分子量 1075.34
MOL 文件 115074-43-6.mol
更新日期 2024/12/23 15:15:09
115074-43-6 結(jié)構(gòu)式 115074-43-6 結(jié)構(gòu)式

基本信息

中文別名
莫匹羅星鈣
莫匹羅星鈣(二水合物)
莫匹羅星鈣 USP標(biāo)準(zhǔn)品
英文別名
Mupirocin Ca
Unii-rg38I2p540
mupirocin calcium hydrate
Mupirocin Calcium (200 mg)
Mupirocin calcium dihydrate
Calcium mupirocin dihydrate
MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD
MUPIROCIN CALCIUM, REFERENCE SPECTRUM EP STANDARD###Mupirocin
5,9-ANHYDRO-2,3,4,8-TETRADEOXY-8-[[3-(2-HYDROXY-1-METHYLPROPYL)OXIRANYL]METHYL]-3-METHYL-[2E,8[2S,3S(1S,2S)]]-L-TALONONO
Calcium 9-[(E)-4-[(2S,3R,4R,5S)-3,4-dihydroxy-5-[[(2S,3S)-3-[(2S,3S)-3-hydroxybutan-2-yl]oxiran-2-yl]methyl]oxan-2-yl]-3-methylbut-2-enoyl]oxynonanoate dihydrate
所屬類別
分析化學(xué):藥典標(biāo)準(zhǔn)品和雜質(zhì)標(biāo)準(zhǔn)品

物理化學(xué)性質(zhì)

熔點132-139 °C
儲存條件-20°C儲存
溶解度Very slightly soluble in water, sparingly soluble in anhydrous ethanol and in methylene chloride.
形態(tài)固體
顏色白色至灰白色
水溶解性Water: 6 mg/mL (5.58 mM)

安全數(shù)據(jù)

危險性符號(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險性描述H315-H317-H319
WGK Germany3
海關(guān)編碼2941906000
毒性mouse,LD50,intravenous,1638mg/kg (1638mg/kg),Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 27, Pg. 195, 1996.

常見問題列表

應(yīng)用
莫匹羅星鈣(二水合物)主要用作抗生素類醫(yī)藥原料。
生物活性
Mupirocin Calcium (Pseudomonic acid A)是mupirocin的鈣鹽形式。Mupirocin是一種天然的巴豆酸衍生物,提取自熒光假單胞菌,抑制細(xì)菌蛋白質(zhì)合成,被用作一種抗生素。
體外研究

Mupirocin Calcium Salt shows a high level of activity against staphylococci and streptococci and against certain gram-negative bacteria. Mupirocin Calcium Salt is highly bound (95% bound) to the protein of human serum, and activity was reduced 10- to 20-fold in the presence of human serum.

體內(nèi)研究

Mupirocin Calcium Salt is well absorbed after oral and parenteral administration but serum antibiotic concentrations were short-lived as a result of extensive degradation to the antibacterially inactive metabolite, monic acid A.

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