112362-50-2
中文名稱
達(dá)福普汀
英文名稱
Dalfopristin
CAS
112362-50-2
分子式
C34H50N4O9S
分子量
690.854
MOL 文件
112362-50-2.mol
更新日期
2024/12/18 11:16:58
112362-50-2 結(jié)構(gòu)式
基本信息
中文別名
達(dá)福司汀達(dá)福普汀
達(dá)福司汀雜質(zhì)
達(dá)福普丁甲磺酸
(1(2)Z,3(2)S,3(3)R,6R,7R,17S)-3(3)-((2-(二乙氨基)乙基)磺?；?-17-羥基-6-異丙基-7,15-二甲基-5-氧雜-11-氮雜-1(4,2)-噁唑-3(1,2)-吡咯烷酰基二十碳六烯酸-8,13,15-三烯-2,4,10,19-四酮
(3R,4R,5E,10E,12E,14S,26R,26AS)-26-[[2-(二乙氨基)乙基]磺?；鵠-8,9,14,15,24,25,26,26A-八氫-14-羥基-4,12-二甲基-3-(1-甲基乙基)-3H-21,18-腈-1H,22H-吡咯并[2,1-C][1,8,4,19] DIOXADIAZAZACYCLOTETRACOSINE-1,7,16,22(4H,17H)-四酮
英文別名
RP 54476112362-50-2
Dalfopristin
Dalfopristin Mesylate
(3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(Diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadi
(3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(DiethylaMino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-diMethyl-3-(1-Methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetr
(3R,4R,5E,10E,12E,14S,26R,26aS)-26-[[2-(Diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-3H-21,18-nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone
3H-21,18-Nitrilo-1H,22H-pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone, 26-[[2-(diethylamino)ethyl]sulfonyl]-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-4,12-dimethyl-3-(1-methylethyl)-, (3R,4R,5E,10E,12E,14S,26R,26aS)-
所屬類別
原料藥：抗生素類藥物物理化學(xué)性質(zhì)
熔點(diǎn)~150°
沸點(diǎn)940.5±65.0 °C(Predicted)
密度1.27±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度DMSO:113.0(Max Conc. mg/mL);163.57(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);144.75(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);144.75(Max Conc. mM)
酸度系數(shù)(pKa)13.18±0.70(Predicted)
形態(tài)Solid
顏色White to yellow
常見問題列表
應(yīng)用
達(dá)福普汀(Dalfopristin)為鏈陽菌素普那霉素IIA的半合成衍生物，達(dá)福普汀和奎奴普丁(Quinupristin)以70/30(w/w)比例組成的抗生素協(xié)同復(fù)合制劑于1999年9月首次上市，商品名：主要用于治療成人致命性耐萬古霉素屎腸球菌(VREF)菌血癥相關(guān)性感染、耐甲氧西林金黃色葡萄球菌(MRSA)及化膿性鏈球菌引起的皮膚及軟組織感染。概述
達(dá)福普汀(Dalfopristin)為鏈陽菌素普那霉素IIA的半合成衍生物，達(dá)福普汀和奎奴普丁(Quinupristin)以70/30(w/w)比例組成的抗生素協(xié)同復(fù)合制劑于1999年9月首次上市，商品名：主要用于治療成人致命性耐萬古霉素屎腸球菌(VREF)菌血癥相關(guān)性感染、耐甲氧西林金黃色葡萄球菌(MRSA)及化膿性鏈球菌引起的皮膚及軟組織感染。生物活性
Dalfopristin (RP54476) 是ostreogyrcin A的半合成類似物。Quinupristin/dalfopristin (Q/D) 是一種親本鏈霉菌素，其活性范圍包括革蘭氏陽性病原體，及對(duì)其他種類的抗菌化合物具有抗性的病原體。靶點(diǎn)
Antibacterial
體外研究
Quinupristin/Dalfopristin(Q/D) is a combination of streptogramins B (Quinupristin) and streptogramins A (Dalfopristin) at 30:70 ratio. Quinupristin/Dalfopristin, a semisynthetic injectable streptogramin, is a combination of 2 synergistic antibiotic components that are derived from pristinamycin: a type B streptogramin (Quinupristin) and a type A streptogramin (Dalfopristin), in a 30:70 weight-to-weight ratio.