105956-99-8
基本信息
克林沙星鹽酸鹽
包被鹽酸可林沙星
7-(3-氨基-1-吡咯烷基)-8-氯-1-環(huán)丙基-6-氟-1,4-二氫-4-氧代-3-喹啉羧酸鹽酸鹽
KR 11095
ClinafoxacinHCl
CLINAFLOXACIN HCL
Clinafloxacinhydrochloride
CLINANFLOXACIN HYDROCHLORIDE
HYDROGEN CLINAFLOXACIN CHLORIDE
Clinafloxacin hydrochloride USP/EP/BP
7-(3-aminopyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxoquinoline-3-carboxylic acid hydrochloride
7-(3-azanylpyrrolidin-1-yl)-8-chloro-1-cyclopropyl-6-fluoro-4-oxo-quinoline-3-carboxylic acid hydrochloride
物理化學(xué)性質(zhì)
常見問題列表
MIC: 1 μg/ml (parC-gyrA mutants, S. pneumonia )
Clinafloxacin exhibits activity against S. pneumonia with an MIC of 1μg/ml for the parC-gyrA mutants.Clinafloxacin hydrochloride has antibacterial activities against target-altered mutant strains of S. aureus . It against Wild type S. aureus , gyr A?mutant S. aureus and gyr A?mutant S. aureus with MIC values of 0.016 μg/ml, 0.063 μg/ml and 0.915 μg/ml, respectively.
Clinafloxacin is very effective for the therapy of penicillin-resistant, ciprofloxacin-susceptible pneumococcal meningitis in the rabbit model. With the CS strain (2349)(Clinafloxacin MIC=0.12 μg/ml), at a dose of 10 mg/kg and 20 mg/kg per day Clinafloxacin achieves an initial reduction at 6 hr. Both are bactericidal at this point but presents regrowth at 24 hr, and the final reduction at 24 hr in mean log cfu/ml is 22.30 and 23.83, respectively. However, With the CR strain (4371)(Clinafloxacin MIC=0.5 μg/ml), Clinafloxacin even at 20 mg/kg per day does not decrease bacterial titers at any time point in this rabbit model of meningitis.