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ChemicalBook--->CAS DataBase List--->85379-09-5

85379-09-5

85379-09-5 Structure

85379-09-5 Structure
IdentificationBack Directory
[Name]

(+)-AJ 76 HYDROCHLORIDE
[CAS]

85379-09-5
[Synonyms]

AJ-76
U-80278A
(+)-AJ76 HCL
(+)-AJ 76 HYDROCHLORIDE
5-methoxy-1-methyl-2-(n-propylamino)tetralin
N-Propyl-1α-methyl-5-methoxytetralin-2α-amine
(1S,2R)-5-methoxy-1-methyl-2-(propylamino)tetralin
(1S,2R)-CIS-5-METHOXY-1-METHYL-2-(N-PROPYLAMINO)-TETRALIN HCL
(1S,2R)-CIS-5-METHOXY-1-METHYL-2-(N-PROPYLAMINO)TETRALIN HYDROCHLORIDE
(1S,2R)-cis-5-Methoxy-1-methyl-2-(N-propylamino)tetralinehydrochloride
(1S)-1,2,3,4-Tetrahydro-5-methoxy-1α-methyl-N-propyl-2α-naphthalenamine
(1S,2R)-1,2,3,4-Tetrahydro-5-methoxy-1-methyl-N-propyl-2-naphthalenamine
[Molecular Formula]

C15H23NO
[MDL Number]

MFCD00672685
[MOL File]

85379-09-5.mol
[Molecular Weight]

233.35
Chemical PropertiesBack Directory
[storage temp. ]

Store at RT
[solubility ]

Soluble to 10 mM in H2O
[form ]

White crystalline solid.
Hazard InformationBack Directory
[Uses]

(+)-AJ 76 Hydrochloride was used in asymmetric synthesis of methoxymethyl(di-n-propylamino)tetralin hydrochloride.
[Definition]

ChEBI: A secondary amino compound that consists of tetralin bearing methyl, propylamino and methoxy groups at positions 1, 2 and 5 respectively. Dopamine receptor antagonist with preferential action at presynaptic receptors (pKi values are 6.95, 6.67, 6.37, 6.21 nd 6.07 at hD3. hD4, hD2S, hD2L and rD2 receptors respectively).
[Biological Activity]

Dopamine receptor antagonist with preferential action at presynaptic receptors (pK i values are 6.95, 6.67, 6.37, 6.21 and 6.07 at hD 3 . hD 4 , hD 2S , hD 2L and rD 2 receptors respectively).
[References]

[1]. kullingsj? h, carlsson a, svensson k. effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-aj76, on locomotor activity and brain da metabolism in the rat. eur j pharmacol, 1991, 205(3): 241-246.
[2]. piercey mf, lum jt, hoffmann we, et al. antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-aj76 and (+)-uh232. brain res, 1992; 588(2): 217-222.
[3]. waters n, hansson l, l?fberg l, et al. intracerebral infusion of (+)-aj76 and (+)-uh232: effects on dopamine release and metabolism in vivo. eur j pharmacol, 1994, 251(2-3): 181-190.
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