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ChemicalBook--->CAS DataBase List--->274694-98-3

274694-98-3

274694-98-3 Structure

274694-98-3 Structure
IdentificationBack Directory
[Name]

LE 300
[CAS]

274694-98-3
[Synonyms]

LE 300
6,7,8,9,14,15-Hexahydro-7-methyl-5H-indolo[3,2-f]benzazecine
7-METHYL-6,7,8,9,14,15-HEXAHYDRO-5H-BENZ[D]INDOLO[2,3-G]AZECINE
6,7,8,9,14,15-HEXAHYDRO-7-METHYL-5H-INDOLO[3,2-F][3]BENZAZECINE
5H-Indolo[3,2-f][3]benzazecine, 6,7,8,9,14,15-hexahydro-7-methyl-
[Molecular Formula]

C20H22N2
[MDL Number]

MFCD00951284
[MOL File]

274694-98-3.mol
[Molecular Weight]

290.4
Chemical PropertiesBack Directory
[Melting point ]

>91°C (dec.)
[storage temp. ]

Store at RT
[solubility ]

DMSO: 26 mg/mL
[form ]

solid
[color ]

Off-White to Pale Beige
[Stability:]

Hygroscopic
Safety DataBack Directory
[WGK Germany ]

3
Hazard InformationBack Directory
[Description]

LE300 is a dopamine D1-like receptor antagonist (Kis = 1.9 and 7.5 nM in CHO cell membranes expressing human dopamine D1 and D5 receptors, respectively) and antagonist of the serotonin (5-HT) receptor subtype 5-HT2A (pA2 = 8.32 in a rat tail artery assay). It is selective for dopamine D1 and D5 over D2L and D4.4 receptors (Kis = 44.7 and 109 nM, respectively). LE300 inhibits the conditioned avoidance response in the pole-jump test in rats (ED50 = 0.94 mg/kg), which is predictive for antipsychotic-like activity. It also reduces locomotor activity in the open field test in rats (ED50 = 0.74 mg/kg).
[Uses]

LE 300 is a potent and selective dopamine receptor antagonist.
[Definition]

ChEBI: LSM-2007 is a member of indoles.
[Biological Activity]

Potent and selective dopamine D 1 receptor antagonist (K i values are 0.08-1.9 nM and 6-45 nM for D 1 and D 2 receptors respectively). Also displays moderate affinity for the 5-HT 2A receptor (K i = 20 nM). Active in vivo .
[storage]

Room temperature
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