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ChemicalBook--->CAS DataBase List--->83643-88-3

83643-88-3

83643-88-3 Structure

83643-88-3 Structure
IdentificationMore
[Name]

(S)-AMPA
[CAS]

83643-88-3
[Synonyms]

AMQ
(S)-AMPA
83643-88-3
glutamate-AMPA
(S)-A-amino-3-hydroxy-5-methylisoxazole -4-propio
(S)-A-AMINO-3-HYDROXY-5-METHYLISOXAZOLE -4-PROPIONI
(S)-amino-3-hydroxy-5-methylisoxazolepropionic acid
(S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid
(S)-A-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
(s)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid
(2S)-2-amino-3-(5-methyl-3-oxo-4-isoxazolyl)propanoic acid
(S)-alpha-Amino-3-hydroxy-5-methyl-4-isoxazol-propionic acid
(S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
(S)-ALPHA-AMINO-3-HYDROXY-5-METHYLISOXAZOLE-4-PROPIONIC ACID
(2S)-2-amino-3-(3-keto-5-methyl-isoxazol-4-yl)propionic acid
(2S)-2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid
(S)-2-aMino-3-(3-hydroxy-5-Methylisoxazol-4-yl)propanoic acid
(2S)-2-azanyl-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid
(2S)-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid
(2S)-2-Amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid
(S)-2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid
4-Isoxazolepropanoic acid, α-amino-2,3-dihydro-5-methyl-3-oxo-, (αS)-
(S)-2-Amino-3-(5-methyl-3-oxo-2,3-dihydroisoxazol-4-yl)propanoic acid
AMQ;GLUTAMATE-AMPA;(S)-A-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
[Molecular Formula]

C7H10N2O4
[MDL Number]

MFCD00672630
[Molecular Weight]

186.17
[MOL File]

83643-88-3.mol
Chemical PropertiesBack Directory
[alpha ]

D28 -21 ±2° (c = 0.19 in water)
[density ]

1.386±0.06 g/cm3(Predicted)
[storage temp. ]

Store at RT
[form ]

White to off-white powder.
[pka]

2.15±0.10(Predicted)
[color ]

White
[Water Solubility ]

Soluble to 100 mM in water
[CAS DataBase Reference]

83643-88-3(CAS DataBase Reference)
Safety DataBack Directory
[Risk Statements ]

R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
[WGK Germany ]

3
Hazard InformationBack Directory
[Uses]

(S)-AMPA is an analogue for AMPA (A611500) a specific agonist for the AMPA receptor which mimics the glutamate receptor.
[Uses]

(S)-AMPA has also been used to activate rostromedial tegmental nucleus (RMTg), to study aversive conditioning in relation with cocaine-induced avoidance behaviors in mice.
[Uses]

Active enantiomer of AMPA that induces apoptosis in cortical neurons
[General Description]

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) activates excitatory postsynaptic currents (EPSC).
[Biological Activity]

Active enantiomer of AMPA (EC 50 = 3.5 μ M). Also available as part of the AMPA Receptor Tocriset™ .
[Biochem/physiol Actions]

Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.
[storage]

Room temperature
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

83643-88-3(sigmaaldrich)
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