| Identification | More | [Name]
6-CYANO-7-NITROQUINOXALINE-2,3-DIONE | [CAS]
115066-14-3 | [Synonyms]
6-CYANO-7-NITROQUINOXALINE-2,3-DIONE
6-CYANO-7-NITROQUINOXALINE-2,3-DIONE 2NA
6-CYANO-7-NITROQUINOXALINE-2,3-DIONE DISODIUM
6-CYANO-7-NITROQUINOXALINE-2,3-DIONE DISODIUM SALT
CNQX
CNQX 2NA
CNQX DISODIUM
CNQX DISODIUM SALT
FG-9065
CNQX DISODIUM KAINATE/AMPA RECEPTOR
CNQX (FG-9065) (6-CYANO-7-NITROQUINO
6-CYANO-7-NITROQUINOXALINE-2,3 (1H,4H)-DIONE
6-Cyano-7-nitroquinoxaline-2,3-dione, FG-9065
2,3-Dioxo-7-nitroquinoxaline-6-carbonitrile
6-Nitro-7-cyanoquinoxaline-2,3-dione
CNOX
1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxalinecarbonitrile
7-Nitro-2,3-dihydroxyquinoxaline-6-carbonitrile | [Molecular Formula]
C9H4N4O4 | [MDL Number]
MFCD00069232 | [Molecular Weight]
232.15 | [MOL File]
115066-14-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Pale Yellow Solid | [Melting point ]
300 °C | [Boiling point ]
374.31°C (rough estimate) | [density ]
1.5507 (rough estimate) | [refractive index ]
1.6590 (estimate) | [RTECS ]
VD1520000 | [storage temp. ]
protect from light | [solubility ]
H2O: 10 mg/mL
| [form ]
solid
| [pka]
8.16±0.20(Predicted) | [color ]
orange to red
| [Water Solubility ]
H2O: >2mg/mL (warmed) | [Usage]
A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively | [Stability:]
Store Tightly Sealed at RT | [CAS DataBase Reference]
115066-14-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [HS Code ]
29335990 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
CNQX disodium salt hydrate has been used as:
- as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
- as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
- as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)
| [Uses]
A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively | [Uses]
CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively, versus IC50 = 25 μM for NMDA receptors). This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors.
| [Definition]
ChEBI: 6-Cyano-7-nitroquinoxaline-2,3-dione is a quinoxaline derivative. | [Biological Activity]
Potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex. | [Biochem/physiol Actions]
Potent, competitive AMPA/kainate glutamate receptor antagonist. | [storage]
Store at -20°C |
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