| Identification | More | [Name]
Calcium citrate | [CAS]
813-94-5 | [Synonyms]
CALCIUM CITRATE
TRICALCIUM DICITRATE
1,2,3-Propanetricarboxylicacid,2-hydroxy-,calciumsalt(2:3)
2,3-propanetricarboxylicacid,2-hydroxy-calciumsalt(2:3)
acicontral
citricacid,calciumsalt(2:3)
citrical
tribasiccalciumcitrate
citric acid sesquicalcium tetrahydrate
Tricalcium Citrate anhydrous
CalciumCitrate/TriCalciumCitrateCalciumCitrateUsp/Fcc
(tri)Calcium(di)citrate,tribasic,anhydrous
Calciumcitrateanhydrous
CALCIUM CITRATE, PHARMA
CALCIUM CITRATE TRIBASIC 4-HYDRATE, PHARMA
Tricalcium dicitrate (anhydrous)
CALCIUM CITRATE USP
DICALCIUMCITRATE
CALCIUMSALTSOFCITRICACID
2-Hydroxy-1,2,3-propanetricarboxylic acid calcium salt (2:3) | [EINECS(EC#)]
212-391-7 | [Molecular Formula]
C12H10Ca3O14 | [MDL Number]
MFCD00078618 | [Molecular Weight]
498.43 | [MOL File]
813-94-5.mol |
| Questions And Answer | Back Directory | [Description]
Calcium citrate, a naturally occurring chemical in most plants and animals, is the calcium salt derived from citric acid. Calcium citrate is present in foods which have naturally occurring citric acid. Calcium citrate is used as a calcium supplement and may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). Calcium citrate may be chemopreventive for colon and other cancers. Calcium citrate is used as an ingredient in dietary supplements, and as a nutrient, sequestrant, buffer, antioxidant, firming agent, acidity regulator (in jams and jellies, soft drinks and wines), as a raising agent and an emulsifying salt. It is also used to improve the baking properties of flours and as a stabilizer.
| [References]
- https://www.cancer.gov
- https://www.drugs.com
- https://www.webmd.com
- https://www.livestrong.com
- https://www.ams.usda.gov
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| Hazard Information | Back Directory | [Chemical Properties]
white powder or white to colourless crystals | [Definition]
ChEBI: Calcium citrate is an organic calcium salt composed of calcium cations and citrate anions in a 3:2 ratio. It has a role as a nutraceutical, a food additive, a food preservative and a flavouring agent. It contains a citrate(3-). | [Production Methods]
Calcium citrate is an intermediate in the isolation of citric acid from the fermentation process by which citric acid is produced industrially. The citric acid in the broth solution is neutralized by calcium hydroxide, precipitating insoluble calcium citrate. This is then filtered off from the rest of the broth and washed to give clean calcium citrate.
The calcium citrate thus produced may be sold as-is, or it may be converted to citric acid using dilute sulfuric acid. | [Flammability and Explosibility]
Nonflammable | [Pharmaceutical Applications]
Calcium citrate is more easily absorbed (bioavailability is 2.5 times higher than calcium carbonate); it is
easier to digest and less likely to cause constipation and gas than calcium carbonate. Calcium citrate can
be taken without food and is more easily absorbed than calcium carbonate on an empty stomach. It is also
believed that it contributes less to the formation of kidney stones. Calcium citrate consists of around 24%
Ca2+, which means that 1000 mg calcium citrate contains around 240 mg Ca2+. The lower Ca2+ content
together with the higher price makes it a more expensive treatment option compared to calcium carbonate,
but its slightly different application field can justify this. | [Biological Activity]
In many individuals, bioavailability of calcium citrate is found to be equal to that of the cheaper calcium carbonate.However, alterations to the digestive tract may change how calcium is digested and absorbed. Unlike calcium carbonate, which is basic and neutralizes stomach acid, calcium citrate has no effect on stomach acid. Individuals who are sensitive to antacids or who have difficulty producing adequate stomach acid should choose calcium citrate over calcium carbonate for supplementation. According to recent research into calcium absorption after gastric bypass surgery , calcium citrate may have improved bioavailability over calcium carbonate in Rouxen- Y gastric bypass patients who are taking calcium citrate as a dietary supplement after surgery. This is mainly due to the changes related to where calcium absorption occurs in the digestive tract of these individuals. |
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