| Identification | More | [Name]
Triethyl acetyl citrate | [CAS]
77-89-4 | [Synonyms]
2-(Acetyloxy)-1,2,3-propanetricarboxylic acid triethyl ester
ACETYL TRIETHYL CITRATE
O-ACETYLCITRIC ACID TRIETHYL ESTER
triethyl acetyl citrate
TRIETHYL O-ACETYLCITRATE
1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, triethyl ester
1,2,3-Propanetricarboxylicacid,2-(acetyloxy)-,triethylester
2,3-propanetricarboxylicacid,2-(acetyloxy)-triethylester
ATEC
Citric acid, acetyl triethyl ester
Citric acid, triethyl ester, acetate
citricacid,acetyltriethylester
citricacid,triethylester,acetate
Citroflex A 2
citroflexa2
o-Acetyl-triethylcitrate
Tricarballylic acid, beta-acetoxytributyl ester
tricarballylicacid,beta-acetoxytributylester
Triethyl 2-(acetyloxy)-1,2,3-propanetricarboxylate
Triethyl 2-acetoxy-1,2,3-propanetricarboxylate | [EINECS(EC#)]
201-066-5 | [Molecular Formula]
C14H22O8 | [MDL Number]
MFCD00049378 | [Molecular Weight]
318.32 | [MOL File]
77-89-4.mol |
| Safety Data | Back Directory | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
1
| [RTECS ]
GE8225000
| [TSCA ]
TSCA listed | [HS Code ]
2918150000 |
| Hazard Information | Back Directory | [Chemical Properties]
Acetyltriethyl citrate occurs as a clear, odorless, practically colorless
oily liquid. | [Uses]
ATEC is produced by the reaction of citric acid triethyl ester
with acetic acid anhydride. It is used as a solvent plasticizer
for cellulose nitrate and cellulose acetate. | [Production Methods]
Acetyltriethyl citrate is prepared by the esterification of citric acid
with ethanol followed by acylation with acetic anhydride. | [General Description]
Certified pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Triethyl 2-acetylcitrate is widely used in hydrophilic adhesives for medications and in biodegradable composition for papermaking and nonwoven production. | [Pharmaceutical Applications]
Acetyltriethyl citrate is used to plasticize polymers in formulated
pharmaceutical coatings. The coating applications include
capsules, tablets, beads and granules for taste masking, immediate
release, sustained-release and enteric formulations. It is also
used in diffusion-controlled release drug delivery systems. | [Safety]
Acetyltriethyl citrate is used in oral pharmaceutical formulations
and is generally regarded as a nontoxic and nonirritating material.
However, ingestion of large quantities may be harmful.
LD50 (cat, oral): 8.5 g/kg
LD50 (mouse, IP): 1.15 g/kg
LD50 (rat, oral): 7 g/kg | [storage]
Acetyltriethyl citrate should be stored in dry, closed containers at
temperatures not exceeding 388℃. When stored in accordance with
these conditions, acetyltriethyl citrate is a stable product. | [Incompatibilities]
Acetyltriethyl citrate is incompatible with strong alkalis and
oxidizing materials. | [Regulatory Status]
Approved in the USA for direct food contact in food films. |
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