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ChemicalBook--->CAS DataBase List--->74191-85-8

74191-85-8

74191-85-8 Structure

74191-85-8 Structure
IdentificationMore
[Name]

[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2,5-dioxabi cyclo[4.4.0]deca-6,8,10-trien-4-yl)methanone
[CAS]

74191-85-8
[Synonyms]

[4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2,5-dioxabi cyclo[4.4.0]deca-6,8,10-trien-4-yl)methanone
DOXAZOSIN
DoxazosinMesylate77883-43-3/Base
DOXAZOSIN(SUBJECTTOPATENTFREE)
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-
UK 33,274
UK 33274
[4-(4-Amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-yl]-(2,5-dioxabi cyclo[4.4.0]deca-6,8,10-trien-4-yl)methanone
DOXAZOSINMESYTL
4-Amino-2-[4-(1,4-benzodioxan-2-carbonyl)piperazin-1-y1]-6,7-dimethoxy quinazoline
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine
1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazine
6,7-Dimethoxy-2-[4-[(2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl]-1-piperazinyl]quinazoline-4-amine
[EINECS(EC#)]

616-059-6
[Molecular Formula]

C23H25N5O5
[MDL Number]

MFCD00800482
[Molecular Weight]

451.48
[MOL File]

74191-85-8.mol
Chemical PropertiesBack Directory
[Melting point ]

289-290°C
[Boiling point ]

718.0±70.0 °C(Predicted)
[density ]

1.371±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

Soluble in DMSO
[form ]

Powder
[pka]

6.52±0.50(Predicted)
[CAS DataBase Reference]

74191-85-8(CAS DataBase Reference)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

ETHYLENE OXIDE-->Quinazoline-->2-(1-Piperazinyl)pyrimidine
Hazard InformationBack Directory
[Description]

Doxazosin mesylate is a selective alpha, blocker indicated for the treatment of hypertension, reportedly of special benefit as a first-line agent in the most hypertonic patient population. Another advantage of doxazosin is its favorable effect on blood lipids; it significantly increases the HDL/total cholesterol ratio and decreases the total cholesterol as well as triglycerides levels.
[Originator]

Pfizer (United Kingdom)
[Uses]

ACIPHEX therapeutic Erosive or Ulcerative Gastroesophageal Reflux Disease
[Definition]

ChEBI: A member of the class of quinazolines that is quinazoline substituted by an amino group at position 4, methoxy groups at positions 6 and 7 and a piperazin-1-yl group at position 2 which in turn is substituted by a 2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl roup at position 4. An antihypertensive agent, it is used in the treatment of high blood pressure.
[Brand name]

Cardura (Pfizer);Carduran.
[General Description]

Doxazosin, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine(Cardura), is a quinazoline compound that selectively inhibitsthe α1-subtype of α-adrenergic receptors. This agentis very useful in the management of hypertension associatedwith pheochromocytoma.
[Clinical Use]

Alpha-adrenoceptor blocker:
Hypertension
Benign prostatic hyperplasia (BPH)
[Drug interactions]

Potentially hazardous interactions with other drugs
Antidepressants: enhanced hypotensive effect with MAOIs.
Avanafil, vardenafil, sildenafil and tadalafil: enhanced hypotensive effect, avoid with tadalafil, start the others at the lowest possible dose.
Beta-blockers: enhanced hypotensive effect; increased risk of first dose hypotensive effect.
Calcium-channel blockers: enhanced hypotensive effect, increased risk of first dose hypotensive effect.
Diuretics: enhanced hypotensive effect, increased risk of first dose hypotensive effect.
Moxisylyte: possibly severe postural hypotension when used in combination.
[Metabolism]

Doxazosin is extensively metabolised in the liver, and excreted in faeces as inactive metabolites (6-hydroxydoxazosin) and a small amount of unchanged drug
Spectrum DetailBack Directory
[Spectrum Detail]

Doxazosin(74191-85-8)1HNMR
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

74191-85-8(sigmaaldrich)
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Tags:74191-85-8 Related Product Information
19216-56-9 19237-84-4 106133-20-4 77883-43-3 63590-64-7 253-82-7 71-43-2 493-09-4 74191-85-8

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