| Identification | More | [Name]
N-(3-Chloropropyl)morpholine | [CAS]
7357-67-7 | [Synonyms]
4-(3-CHLORO-PROPYL)-MORPHOLINE
4-(3-CHLOROPROPYL)MORPHOLINE HCL
4-(3-CHLOROPROPYL)-MORPHOLINE HYDROCHLORIDE
IFLAB-BB F2108-0002
MORPHOLINOPROPYL CHLORIDE HYDROCHLORIDE
N-(3-CHLOROPROPYL)MORPHOLINE HCL
3-morpholinopropylchloride
4-(3-chloropropyl)-morpholin
N-(3-Chloropropyl)morpholine
1-Chloro-3-morpholinopropane
3-(Morpholin-4-yl)propyl Chloride
3-Chloro-1-(morpholin-4-yl)propane
NSC 28831
NSC 38889 | [EINECS(EC#)]
461-510-0 | [Molecular Formula]
C7H14ClNO | [MDL Number]
MFCD00035333 | [Molecular Weight]
163.65 | [MOL File]
7357-67-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
NA | [Boiling point ]
115°C/25mmHg(lit.) | [density ]
1.0409 g/cm3 | [refractive index ]
1.4720-1.4760 | [RTECS ]
QE0488000 | [Fp ]
91 °C | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Oil | [pka]
7.03±0.10(Predicted) | [color ]
Colourless to Yellow | [Specific Gravity]
1.08 | [Usage]
Gefitinib intermediate | [InChI]
InChI=1S/C7H14ClNO/c8-2-1-3-9-4-6-10-7-5-9/h1-7H2 | [InChIKey]
PQECODMSWJOUAT-UHFFFAOYSA-N | [SMILES]
N1(CCCCl)CCOCC1 | [CAS DataBase Reference]
7357-67-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HazardClass ]
IRRITANT | [HS Code ]
2934999090 |
| Hazard Information | Back Directory | [Description]
4-(3-Chloropropyl)morpholine is a hydrochloride salt of the potent inhibitor 4-(3-chloropropyl)morpholine. It has an inhibitory effect on cancer, and is used in chromatographic science to separate amines from aliphatic hydrocarbons. 4-(3-Chloropropyl)morpholine inhibits epidermal growth factor (EGF) and has been shown to have a potent inhibitory effect on EGF receptor tyrosine kinase activity. It also inhibits the proliferation of cells by inhibiting DNA synthesis. This compound causes cell death through the inhibition of protein synthesis, which may be due to its ability to inhibit nucleophilic reactions that are involved in protein synthesis. 4-(3-Chloropropyl)morpholine can also fluoresce under UV light, which makes it useful for research purposes. | [Chemical Properties]
Pale Yellow Oil | [Uses]
Gefitinib intermediate | [Application]
4-(3-Chloropropyl)morpholine is an organic synthetic reagent or pharmaceutical intermediate used in the synthesis of gefitinib. It has cancer-inhibiting properties and inhibits epidermal growth factor (EGF). It also inhibits cell proliferation by inhibiting DNA synthesis. |
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