成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->72479-26-6

72479-26-6

72479-26-6 Structure

72479-26-6 Structure
IdentificationMore
[Name]

1-[2-(2,4-Dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazole
[CAS]

72479-26-6
[Synonyms]

FENTICONAZOLE
FENTICONAZOLE IMPURITY D(RS)-1-[2-(2,4-DICHLOROPHENYL)-2-HYDROXYETHYL]-3-[4-(PHENYLSUPHANYL)BENZYL]IMIDAZOLIUM NITRATE EPF(CRM STANDARD)
1-[2-(2,4-Dichlorophenyl)-2-[[4-(phenylthio)phenyl]methoxy]ethyl]-1H-imidazole
1-[2,4-Dichloro-β-[[4-(phenylthio)benzyl]oxy]phenethyl]-1H-imidazole
1-[β-[[4-(Phenylthio)benzyl]oxy]-2,4-dichlorophenethyl]-1H-imidazole
[Molecular Formula]

C24H20Cl2N2OS
[MDL Number]

MFCD00865611
[Molecular Weight]

455.4
[MOL File]

72479-26-6.mol
Chemical PropertiesBack Directory
[CAS DataBase Reference]

72479-26-6(CAS DataBase Reference)
Hazard InformationBack Directory
[Originator]

Lomexin,Effik
[Uses]

Antifungal.
[Uses]

Isotope labelled Fenticonazole Nitrate broad spectrum antimycotic; also active as antibacterial. Antifungal (topical).
[Definition]

ChEBI: 1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]imidazole is a member of the class of imidazoles that carries a 2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl group at position 1. It is a member of imidazoles, a dichlorobenzene, an ether and an aryl sulfide.
[Manufacturing Process]

1-(2',4'-Dichlorophenyl)-2-chloroethanol:
49.5 g of sodium borohydride were added slowly and in small parts to a suspension of 233 g of 1-(1'-hydroxy-2'-chloroethyl)-2,4-dichlorobenzene in 1 liter of methanol stirred at room temperature. The solution thus obtained was stirred at room temperature for a further two hours, and it was then poured into 1 liter of 5 N hydrochloric acid cooled with ice. After extraction with ethyl acetate or chloroform, the extract was washed with water, with 1 N sodium hydroxide, then again with water until neutrality, and finally with a saturated sodium chloride solution. The extract was dried, the solvent evaporated off and 220 g of an oil were obtained. The oil solidified on standing and the solid 1-(2',4'-dichlorophenyl)-2-chloro-ethanol melted at 48-51°C.
1-(2',4'-Dichlorophenyl)-2-(N-imidazolyl)ethanol:
30 g of sodium were added to a solution of 88.5 g of imidazole in 600 ml of methanol; the solvent was then evaporated off. The residue was dissolved in 300 ml of dimethylformamide and heated to 115-120°C. To the solution so obtained was added, dropwise and under stirring, a solution of 225 g of 1- (2',4'-dichlorophenyl)-2-chloroethanol in 400 ml of dimethylformamide. The mixture was heated to 115-120°C and maintained at that temperature for 20 min and, after subsequent cooling to 40°C, 2500 ml of iced water were added under vigorous stirring. The product precipitated under stirring over a period of about two hours, the upper liquid was then decanted off, a further 2500 ml of water were added and, after standing, the whole was filtered. The precipitate thus obtained was dried and crystallized from toluene. 170 g of the 1-(2',4'-dichlorophenyl)-2-(N-imidazolyl)ethanol, melting at 134-135°C, was obtained.
METHOD 1:
A solution of 2.57 g of 1-(2',4'-dichlorophenyl)-2-(N-imidazolyl)ethanol in 10 ml of hexamethylphosphoramide was dropped at 25°C into a suspension of 0.52 g of sodium hydride (50% in oil) in 5 ml of hexamethylphosphoramide. When hydrogen emission was over, the salification was completed by heating for 1 hour at 50°C. After cooling to 25°C, 2.58 g of 1-chloromethyl-4- phenylthiobenzene were added. The temperature was raised to 50°C and maintained at that temperature for 12 hours. At the end of the reaction, the mixture was poured into 200 ml of water, the product was extracted with diethyl ether, the solvent was evaporated off and the residue was purified twice on a silica gel column, using ethyl acetate as eluant and testing the various fractions by TLC. The solvent was evaporated off the middle fractions to give 2.4 g of the 1-[2,4-dichloro-beta-[[p-(phenylthio)benzyl]oxy] phenethyl]imidazole as a yellowish oil, showing a single spot on TLC.
METHOD 2:
0.66 g of sodium hydride (50% in oil) were added at 20-30°C and under nitrogen atmosphere to 3.86 g of 1-(2',4'-dichlorophenyl)-2-(N-imidazolyl) ethanol in 15 ml of dimethylsulphoxide (dried on calcium hydride). The mixture was heated under stirring at 50-60°C until gas emission was over. After cooling to 20-25°C, 0.5 g of potassium iodide were added and slowly a solution of 3.51 g of 1-chloromethyl-4-phenylthiobenzene in 4 ml of dimethylsulphoxide was dropped in. The mixture was stirred at 20-25°C until addition of the 1-chloromethyl-4-phenylthiobenzene was over. The mixture was then poured into 150 ml of water and extracted with diethyl ether. To the etheric solution, after drying on anhydrous sodium sulphate, was added excess 4 N nitric acid solution in diethyl ether: the desired product precipitated as nitrate, an oil which solidified on standing. After standing for 20 hours, the etheric liquid was decanted off and the residue was crystallized from ethanol. The nitrate thus obtained, not completely pure, was dissolved in water and excess sodium carbonate was added in order to liberate the base which was then extracted with ethyl acetate. The base, obtained by filtration, was purified on a silica gel column using ethyl acetate as eluant. The combined fractions containing the desired product were evaporated to dryness. The residue was dissolved in diethyl ether, again transformed into the nitrate and crystallized from ethanol. Yield: 3.1 g of a white crystalline powder, melting at 136°C; λmax 252 nm (methanol).
[Therapeutic Function]

Antifungal
72479-26-6 suppliers list
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: https://www.dideu.com
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Website: www.afinechem.com/index.html
Company Name: Henan Fengda Chemical Co., Ltd
Tel: +86-371-86557731 +86-13613820652 , +86-13613820652
Website: http://www.fdachem.com
Company Name: Suzhou ARTK Medchem Co., Ltd.
Tel: +86-512-68323658 +86-18168183658 , +86-18168183658
Website:
Company Name: TargetMol Chemicals Inc.
Tel: +8613564774135 , +8613564774135
Website:
Company Name: SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel: +8613817748580 , +8613817748580
Website: www.kean-chem.com
Company Name: Symed Laboratories Ltd  
Tel: +91-9505426644 +91-9505426644
Website: www.symedlabs.com
Company Name: BDR Pharmaceuticals International Pvt Ltd  
Tel: +91-2240560560 +91-7718884418
Website: www.bdrpharma.com
Company Name: Viyash Life Sciences Pvt Ltd  
Tel: +91-4023635052 +91-4023635052
Website: www.viyash.com
Company Name: SEUTIC  
Tel: +91-8309787199 +91-8309787199
Website: www.seutic.com
Company Name: SURYA LIFE SCIENCES LIMITED  
Tel: +91-2646226290 +91-9428511112
Website: www.suryalifesciences.com
Company Name: Mainchem Co., Ltd.  
Tel: +86-0592-6210733
Website: https://www.mainchem.com
Company Name: Chemwill Asia Co.,Ltd.  
Tel: 86-21-51086038
Website: www.chemwill.com
Company Name: LGM Pharma  
Tel: 1-(800)-881-8210
Website: www.lgmpharma.com
Company Name: T&W GROUP  
Tel: 021-61551611 13296011611
Website: www.trustwe.com/
Company Name: Wuhan FengyaoTonghui Chemical Products Co., Ltd.  
Tel: 027-87466105 15377573527
Website: www.is0513.com/showsupplierproductslist30440/0_en.htm
Company Name: Chengdu Saint - Kay Biotechnology Co., Ltd.  
Tel: 028-85157043 15882256948
Website: http://www.is0513.com/ShowSupplierProductsList30701/0.htm
Tags:72479-26-6 Related Product Information
23593-75-1 64872-77-1 171228-49-2 65472-88-0 73151-29-8 24155-42-8 72479-26-6