| Identification | Back Directory | [Name]
trimetozine | [CAS]
635-41-6 | [Synonyms]
V 7
Opalene
PS 2383
PS-2383
NSC-62939
Trioxazin
Trioxazine
Sedoxazine
TriMetozin
Abbott-22370
Trifenoxazine
morpholino-(3,4,5-trimethoxyphenyl)methanone
4-Morpholinyl(3,4,5-triMethoxyphenyl)Methanone
morpholin-4-yl-(3,4,5-trimethoxyphenyl)methanone
N-(3,4,5-TriMethoxybenzoyl)tetrahydro-1,4-oxazine
4-(3,4,5-TriMethoxybenzoyl)tetrahydro-1,4-oxazine
Methanone, 4-Morpholinyl(3,4,5-triMethoxyphenyl)- | [EINECS(EC#)]
211-236-0 | [Molecular Formula]
C14H19NO5 | [MDL Number]
MFCD00023351 | [MOL File]
635-41-6.mol | [Molecular Weight]
281.306 |
| Chemical Properties | Back Directory | [Melting point ]
120-122° | [Boiling point ]
423.97°C (rough estimate) | [density ]
1.1755 (rough estimate) | [refractive index ]
1.5230 (estimate) | [form ]
Solid | [pka]
-1.60±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
A sedative with mild tranquilizing effects. It has been used therapeutically in the treatment of anxiety. It is also a metabolite of the antisecretory and antiulcer drug Trithiozine. | [Uses]
antiurolithic, depigmentation, radiation protectant | [Originator]
Opalene,Theraplix,France,1966 | [Definition]
ChEBI: 4-morpholinyl-(3,4,5-trimethoxyphenyl)methanone is a member of morpholines. | [Manufacturing Process]
46 g 3,4,5-trimethoxybenzoyl chloride are dissolved in 300 ml anhydrous
benzene and 25 g triethylamine and thereafter 19 g anhydrous morpholine are
added in small portions with ice-cooling. The solution is boiled for 2 hours
under reflux. The precipitate is filtered off, and the solution is washed with
dilute sulfuric acid, then with sodium hydrogen carbonate solution and finally
with water, and then evaporated. The residual yellow oil soon crystallizes; the
crystalline mass of the desired material is taken up with ether, filtered and
then recrystallized from 90% ethanol, from which it separates in prisms. It is
slightly soluble in water. Yield: 80%. melting point 120°C to 122°C. | [Therapeutic Function]
Sedative |
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