| Identification | More | [Name]
Phenytoin sodium | [CAS]
630-93-3 | [Synonyms]
5,5-diphenyl-2,4-imidazolidinedione monosodium salt
5,5-DIPHENYL-2,4-IMIDAZOLIDINEDIONE SODIUM SALT
5,5-DIPHENYLHYDANTOIN SODIUM
5,5-DIPHENYLHYDANTOIN SODIUM SALT
DILANTIN
DIPHENYLHYDANTOIN SODIUM SALT
PHENYLTOIN SODIUM
PHENYTOIN SODIUM
PHENYTOIN SODIUM SALT
sodium 5,5-diphenyl-2,4-imidazolidinedione
SODIUM 5,5-DIPHENYLHYDANTOIN
SODIUM DIPHENYLHYDANTOIN
4-imidazolidinedione,5,5-diphenyl-monosodiumsalt
5,5-diphenyl-hydantoimonosodiumsalt
5,5-diphenylhydantoinsodiumsigmaultra
5,5-diphenyl-hydantoisodiumsalt
alepsin
aleviatinsodium
auranile
denylsodium | [EINECS(EC#)]
211-148-2 | [Molecular Formula]
C15H12N2NaO2 | [MDL Number]
MFCD00069674 | [Molecular Weight]
275.26 | [MOL File]
630-93-3.mol |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder, slightly hygroscopic. | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
aqueous base: soluble
| [form ]
Crystalline Powder | [color ]
White to almost white | [Merck ]
7322 | [BCS Class]
2 | [Stability:]
Hygroscopic | [InChIKey]
FJPYVLNWWICYDW-UHFFFAOYSA-M | [CAS DataBase Reference]
630-93-3(CAS DataBase Reference) | [EPA Substance Registry System]
630-93-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R43:May cause sensitization by skin contact.
R62:Possible risk of impaired fertility.
R63:Possible risk of harm to the unborn child. | [Safety Statements ]
S22:Do not breathe dust .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
MU1400000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29332100 | [Safety Profile]
Confirmed
carcinogen. Experimental teratogen. Other
experimental reproductive effects. Poison by
ingestion, subcutaneous, intravenous, and
intraperitoneal routes. Human systemic
effects by ingestion: anorexia, respiratory
depression, nausea or vomiting,
hemorrhage, dermatitis, and endocrine
effects. Mutation data reported. An
anticonvulsant and cardiac depressant used
for the treatment of grand mal and
psychomotor seizures. When heated to
decomposition it emits very toxic fumes of
NOx and Na2O. | [Toxicity]
LD50 orally in mice: 490 mg/kg (Fink, Swinyard) |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder, slightly hygroscopic. | [Uses]
antibacterial | [Uses]
Antiepileptic | [Brand name]
Diphenylan (Lannett); Phenytek (Mylan);
Phenytex (Watson) [Name previously used: Diphenylhydantoin Sodium.]. | [General Description]
Phenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt. Solutions for parenteraladministration contain 40% propylene glycol and10% alcohol to dissolve the sodium salt. | [Clinical Use]
Phenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication. | [Carcinogenicity]
Phenytoin and its sodium salt are reasonably anticipated to be human carcinogens based on sufficient evidence from studies in experimental animals. | [storage]
Store at RT |
|
|