| Identification | More | [Name]
2-Amino-2-methylpropionic acid | [CAS]
62-57-7 | [Synonyms]
2-amino-2-methylpropionic acid
2-AMINOISOBUTYRIC ACID
2-METHYLALANINE
A-AMINO ISO-BUTYRIC ACID
AIB
ALPHA-AMINOISOBUTYRIC ACID
ALPHA-METHYLALANINE
DL-2-AMINO-ISO-BUTYRIC ACID
H-2-AMINOISOBUTYRIC ACID
H-AIB-OH
H-ALA(ME)-OH
H-ALPHA-METHYLALANINE
H-(ME)ALA-OH
N-ME-ALANINE
N-ME-ALA-OH
N-METHYL-L-ALANINE
N-METHYL-L-AMINOPROPANOIC ACID
RARECHEM EM WB 0051
2-Amino-2-methylpropanoic acid
2-amino-2-methylpropanoicacid | [EINECS(EC#)]
200-544-0 | [Molecular Formula]
C4H9NO2 | [MDL Number]
MFCD00008049 | [Molecular Weight]
103.12 | [MOL File]
62-57-7.mol |
| Questions And Answer | Back Directory | [Applications]
2-Methylalanine is an Alanine (A481400) derivative. Alanine is an amino acid that occurs naturally in nature. It is a functional component in the alanine cycle which regulates the level of alanine aminotransferases which can be used as a diagnostic tool to predict type II diabetes.
| [Description]
2-Aminoisobutyric acid, also known as alpha-methylalanine or a-aminoisobutanoate, belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). 2-Aminoisobutyric acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. 2-Aminoisobutyric acid exists in all living organisms, ranging from bacteria to humans. Outside of the human body, 2-Aminoisobutyric acid has been detected, but not quantified in, milk (cow). This could make 2-aminoisobutyric acid a potential biomarker for the consumption of these foods. Aminoisobutyric acid is a nonprotein amino acid (is an end product of pyrimidine metabolism) excreted in the urine of about 5% of healthy individuals , and high excretion is an autosomal recessive phenotype.
| [source]
2-aminoisobutyric acid is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. With the exception of a few bacteria, it is non-metabolisable, and therefore used in bioassays. It derives from a propionic acid and an isobutyric acid.
|
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3 | [RTECS ]
AY7000000 | [TSCA ]
Yes | [HazardClass ]
IRRITANT | [HS Code ]
29224995 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder
| [Uses]
2-Aminoisobutyric Acid inotransferases which can be used as a diagnostic tool to predict type II diabetes.
| [Definition]
ChEBI: A rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin. With the exception of a few bacteria, it is non-metabolisable, and therefore used in bioassays. | [Preparation]
α-Aminoisobutyric Acid is prepared from Acetone (Blatt: Org. Synth. CoIl. vol. H, page 29, 1943) or by the Bucherer method (Org. Synth. vol. XX, 1940, page 42).
| [Synthesis Reference(s)]
The Journal of Organic Chemistry, 29, p. 1148, 1964 DOI: 10.1021/jo01028a036 | [Solubility in organics]
poorly soluble in alcohol, insoluble in oils.
| [storage]
Desiccate at -20°C | [Purification Methods]
Crystallise the acid from aqueous EtOH and dry it at 110o. [Zelinski & Stadnikoff Chem Ber 39 1726 1906, Beilstein |
|
|