| Identification | More | [Name]
Diethyl methylmalonate | [CAS]
609-08-5 | [Synonyms]
DIETHYL 2-METHYLPROPANEDIOATE
DIETHYL METHYLMALONATE
METHYLMALONIC ACID DIETHYL ESTER
RARECHEM AL BI 0301
2-methyl-malonicaciddiethylester
2-methyl-propanedioicaciddiethylester
Diethyl 2-methylmalonate
Diethylisosuccinate
dlethylmethylmalonate
Ethyl methylmalonate
Malonic acid, methyl-, diethyl ester
methyl-propanedioicacidiethylester
Propanedioic acid, 2-methyl-, diethyl ester
Methoxymalonic Acid Diethyl Ester
Methylmalonic acid diethyl ester~Methylpropanedioic acid diethyl ester
DIETHYL METHYLMALONATE 99% (GC)
Diethylmethylmalonate,99%
Diethyl methylpropanedioate
Methyl-propanedioic acid diethyl ester
Diethyl a-methylmalonate | [EINECS(EC#)]
210-175-7 | [Molecular Formula]
C8H14O4 | [MDL Number]
MFCD00009162 | [Molecular Weight]
174.19 | [MOL File]
609-08-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear liquid | [Boiling point ]
198-199 °C (lit.)
78-80 °C/10 mmHg | [density ]
1.022 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.413(lit.)
| [Fp ]
170 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
1000mg/l | [form ]
Liquid | [pka]
13.13±0.46(Predicted) | [color ]
Clear colorless | [Specific Gravity]
1.013 | [PH]
8 (1000mg/l, H2O, 20℃) | [Water Solubility ]
immiscible | [Usage]
Diethyl methylmalonate is used as intermediate for the syntheses of pharmaceuticals, e.g. non-steroidal anti-inflammatory agents with 2-acrylpropionic acid structures acrylpropionic acid structure. It is also used in the flavour and fragrance industries. Product Data Sheet | [BRN ]
637028 | [InChIKey]
UPQZOUHVTJNGFK-UHFFFAOYSA-N | [LogP]
1.256 (est) | [CAS DataBase Reference]
609-08-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Propanedioic acid, methyl-, diethyl ester(609-08-5) | [EPA Substance Registry System]
609-08-5(EPA Substance) |
| Safety Data | Back Directory | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29171990 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
DIETHYL OXALPROPIONATE | [Preparation Products]
2,5-Dimethylpyridine-->4,6-DIHYDROXY-5-METHYLPYRIMIDINE-->2(1H)-PYRIDINONE, 4-HYDROXY-3,6-DIMETHYL--->7-CHLORO-4-HYDROXY-3-QUINOLINECARBOXYLIC ACID-->ethyl 4-hydroxy-7-methyl-1,8-naphthyridine-3-carboxylate-->Ethyl 2-methyl-4-pentenoate-->BIS(2-THIENYL) KETONE-->DIETHYL METHYL(2-METHYLBUTYL)MALONATE-->2-(diMethylaMino)-5-MethylpyriMidine-4,6-diol-->4-(2,2-Dicarboethoxy-propyl)phenylacetic Acid-->Malonic acid, (3-isothiazolylmethyl)methyl-, diethyl ester-->2H-Pyrano[3,2-c]pyridine-2,5(6H)-dione, 4-hydroxy-3,6,7-trimethyl- (9CI) |
| Hazard Information | Back Directory | [Chemical Properties]
Clear liquid | [Uses]
Diethyl methylmalonate is used as intermediate for the syntheses of pharmaceuticals, e.g. non-steroidal anti-inflammatory agents with 2-acrylpropionic acid structures acrylpropionic acid structure. It is also used in the flavour and fragrance industries. Product Data Sheet | [General Description]
Diethyl methylmalonate reacts with 2-cyclohexenone under abnormal Michael conditions form 2-(3-oxocyclohexyl)-2-cyclohexenone. It causes the alkylation of poly(chloromethylstyrene) during pahse transfer catalysis. | [Synthesis]
Diethyl methylmalonate is produced by the following method:1) by condensing Ethylpropionate with Diethyloxalate, followed by heating of the reaction product. 2) from Diethylmalonate plus Sodium and Methyl iodide.
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