成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->58-05-9

58-05-9

58-05-9 Structure

58-05-9 Structure
IdentificationMore
[Name]

Folinic acid
[CAS]

58-05-9
[Synonyms]

FOLINIC ACID
LEUCOVORIN
5-formyl-5,6,7,8-tetrahydropteroyl-l-glutamicacid
leucoverin
5-formyl-5,6,7,8-tetrahydrofolate
5-formyltetrahydrofolate
5-formyltetrahydrofolic acid
N5-formyl-5,6,7,8-tetrahydrofolate
N5-formyl-tetrahydrofolate
2-[4-[(2-amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid
N5-Formyl-H4F
(6R,S)-5-Formyltetrahydrofolate
10-Formyl-7,8-dihydrofolic acid
5-Formyl-5,6,7,8-tetrahydrofolic acid
5-Formyltetrahydropteroylglutamic acid
Glutamic acid, N-[p-[[(2-amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]-, L-(8CI)
Leucal
levoleucovorin
L-Glutamic acid, N-[4-[[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-(9CI)
l-Leucovorin
[EINECS(EC#)]

200-361-6
[Molecular Formula]

C20H23N7O7
[MDL Number]

MFCD00867488
[Molecular Weight]

473.44
[MOL File]

58-05-9.mol
Chemical PropertiesBack Directory
[Appearance]

Crystals. Sparingly soluble in water.
[Melting point ]

245°C (rough estimate)
[alpha ]

D20 +14.26° (c = 3.42 as anhydr Ca salt)
[Boiling point ]

573.92°C (rough estimate)
[density ]

1.4485 (rough estimate)
[refractive index ]

1.6800 (estimate)
[storage temp. ]

under inert gas (nitrogen or Argon) at 2–8 °C
[pka]

3.1, 4.8, 10.4(at 25℃)
[Water Solubility ]

>1350g/L(25 ºC)
[CAS DataBase Reference]

58-05-9(CAS DataBase Reference)
Questions And AnswerBack Directory
[Description]

Folinic acid, chemical name N-[4-[(2-amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridyl) Methyl]amino]benzoyl-L-glutamic acid has been widely used in cancer combined chemotherapy. Folinic acid enters the human body through the ingestion and absorption pathway of folate. Folinic acid (calcium folinate) is a special form of reduced folic acid (folate).
[Uses]

1. It is mainly used as an antidote for folic acid antagonists (such as methotrexate, pyrimethamine or trimethoprim, etc.).2. It is used to prevent severe toxic effects caused by methotrexate overdose or high-dose treatment.3. Megaloblastic anemia caused by folic acid deficiency.4. When combined with fluorouracil, it is used to treat advanced colon cancer and rectal cancer. 
[Characteristics]

L-leucovorin is used as an anti-tumor antidote and anti-megaloblastic anemia adjuvant. Its dosage is 1/2 of folinic acid. L-leucovorin does not need to be reduced by dihydrofolate reductase to participate in the use of folate as a The reaction is derived from carbon units, and L-leucovorin can actively or passively pass through the cell membrane; the basic function of L-leucovorin is the same as folic acid, but the effect is better than folic acid. At the same time, L-leucovorin also has the effect of stimulating the growth and maturation of white blood cells, which can improve the growth and maturation of white blood cells. 
[Pharmacology]

Folic acid (pteroylglutamic acid), an essential water-soluble vitamin, consists of a pteridine ring joined to PABA (para-aminobenzoic acid) and glutamic acid.3 Folic acid is the most common of the many folate congeners that exist in nature and are essential for normal cellular metabolic functions. Folic acid is rarely called vitamin B9. After absorption, folic acid is reduced by dihydrofolic acid reductase (DHFR) to dihydrofolic acid and then tetrahydrofolic acid (THF), which accepts one-carbon groups. Tetrahydrofolic acid serves as the precursor for several biologically active forms of folic acid, including 5-formyltetrahydrofolic acid (5-formyl THF), which is best known as folinic acid, leucovorin, and citrovorum factor. 
[Preparation]

In a 1L reaction flask, first add 0.45L of pure water, heat to 55-60℃ with stirring, then add 15g (0.0245mol, water 16.4%) of levofolinate, keep it at 55-60℃, and stir to It is almost dissolved, and the temperature is lowered to 0-10°C first, and an aqueous sodium carbonate solution (2.6g sodium carbonate (0.0245mol) dissolved in 45mL of pure water) is added dropwise, keeping the temperature at 0-10°C, after dripping, keep warm and stir for 1 hour. The precipitated solid is filtered out, the filter cake is washed once with 20 ml of pure water, and the filtrate is the sodium levofolinate solution. Put the filtrate into a 1L reaction flask, stir and lower the temperature to 0-5°C, control the temperature of the reaction system at 0-5°C, and add 1N dilute hydrochloric acid uniformly. When the pH of the acidification end point is 2.0-2.5, stop the dripping. Stir for about 30 minutes, then stand and age for 30 minutes, filter, and wash the filter cake twice with 75 mL of pure water. The wet product is freeze-dried to obtain 9.1 g of Folinic acid. Yield: 78%
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

(2S)-2-[[4-[(2-Amino-5-formyl-4-oxo-1,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid(58-05-9).msds
Safety DataBack Directory
[Hazardous Substances Data]

58-05-9(Hazardous Substances Data)
Hazard InformationBack Directory
[Chemical Properties]

Crystals. Sparingly soluble in water.
[Originator]

Leucovorin calcium,AstraZeneca
[Definition]

ChEBI: A formyltetrahydrofolic acid in which the formyl group is located at position 5.
[Manufacturing Process]

5,10-Methenyl-5,6,7,8-tetrahydrofolic acid, chloride hydrochloride dihydrate (20 g) was added in one portion to 100 ml water at 60°C followed by N,Ndiethylethanolamine (14.9 g) which adjusted the pH to 6. The mixture was maintained at reflux for 5 hours and the pH kept between 5.7 and 6.2 by addition of N,N-diethylethanolamine. The mixture was cooled, synthetic magnesium silicate (15 g) added and slurried, and filtered through celite and diluted with 40 ml SD3A (95% ethanol with 5% methanol). The filtrate was kept at -5°C for 16 hours, aqueous calcium chloride (4.0 g) was added dropwise to the cold filtrate, and the precipitate filtered, washed with SD3A (100 ml) and with ethyl acetate (100 ml) and dried under reduced pressure.
[Brand name]

Wellcovorin (GlaxoSmithKline).
[Therapeutic Function]

Antidote (folic acid antagonists), Antianemic
Spectrum DetailBack Directory
[Spectrum Detail]

Folinic acid(58-05-9)MS
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

58-05-9(sigmaaldrich)
58-05-9 suppliers list
Company Name: Hebei Chuanghai Biotechnology Co,.LTD
Tel: +86-13131129325 , +86-13131129325
Website: www.chuanghaibio.com
Company Name: airuikechemical co., ltd.
Tel: +undefined86-15315557071 , +undefined86-15315557071
Website: airuikechemical.com/
Company Name: Shanghai Daken Advanced Materials Co.,Ltd
Tel: +86-371-66670886
Website: https://www.dakenchem.com/
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512 , +86-19937530512
Website: https://www.tianfuchem.com/
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: Xiamen AmoyChem Co., Ltd
Tel: +86-86-5926051114 +8618959220845 , +8618959220845
Website: www.amoychem.com/
Company Name: Shandong chuangyingchemical Co., Ltd.
Tel: 18853181302
Website: www.is0513.com/ShowSupplierProductsList103425/0.htm
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873 , +86-86-13650506873
Website: http://www.chemdad.com/
Company Name: CONIER CHEM AND PHARMA LIMITED
Tel: +8618523575427 , +8618523575427
Website: http://www.conier.com/
Company Name: SIMAGCHEM CORP
Tel: +86-13806087780 , +86-13806087780
Website: http://www.simagchem.com/
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000 , +1-00000000000
Website: https://www.targetmol.com/
Company Name: Hefei TNJ Chemical Industry Co.,Ltd.
Tel: +86-0551-65418671 +8618949823763 , +8618949823763
Website: www.tnjchem.com
Company Name: Dideu Industries Group Limited
Tel: +86-29-89586680 +86-15129568250 , +86-15129568250
Website: https://www.dideu.com
Company Name: AFINE CHEMICALS LIMITED
Tel: +86-0571-85134551
Website: www.afinechem.com/index.html
Company Name: Lianyungang Jinkang Hexin Pharmaceutical Co., Ltd.
Tel: 0518-81087819
Website: www.magnafolate.com
Company Name: Lianyungang Jinkang Hexin Pharmaceutical Co., Ltd.
Tel: 0518-81087819
Website: www.magnafolate.com
Company Name: Finetech Industry Limited
Tel: +86-27-87465837 +8618971612321 , +8618971612321
Website: https://www.finetechnology-ind.com/
Company Name: Dayang Chem (Hangzhou) Co.,Ltd.
Tel: 571-88938639 +8617705817739 , +8617705817739
Website: https://www.dycnchem.com/
Tags:58-05-9 Related Product Information
591-27-5 56-40-6 77-92-9 59-30-3 60-32-2 94-36-0 51-83-2 77-86-1 55896-93-0 712-29-8 151533-22-1 1391194-56-1 4271-30-1 2800-34-2 1391068-26-0 47707-78-8 3432-99-3 2236-60-4