| Identification | More | [Name]
Isobutyl chloroformate | [CAS]
543-27-1 | [Synonyms]
carbonochloridic acid 2-methylpropyl ester
CHLOROFORMIC ACID ISOBUTYL ESTER
IBCF
Isobutyl chloocarbonate
ISOBUTYL CHLOROCARBONATE
ISOBUTYL CHLOROFORMATE
2-methyl-1-propylchlorocarbonate
2-Methylpropyl carbonochloridate
2-Methylpropyl chloroformate
2-methylpropylchloroformate
Chlorocarbonic acid isobutyl ester
chlorocarbonicacidisobutylester
Formic acid, chloro-, isobutyl ester
Isobutyl chloridocarbonate
#niso-Butyl chloroformate
Isobutylchloroformate,~90%
Isobutylchloroformate,98%
Isobutyl chloroformate 98%
Isobutylchloroformate99%
isobutyl chloformate | [EINECS(EC#)]
208-840-1 | [Molecular Formula]
C5H9ClO2 | [MDL Number]
MFCD00000642 | [Molecular Weight]
136.58 | [MOL File]
543-27-1.mol |
| Chemical Properties | Back Directory | [Appearance]
A combustible, colorless to light-colored
liquid. | [Melting point ]
-80°C | [Boiling point ]
128.8 °C(lit.)
| [density ]
1.053 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.33 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.407(lit.)
| [Fp ]
82 °F
| [storage temp. ]
2-8°C
| [solubility ]
benzene: miscible | [form ]
Liquid | [color ]
Clear | [Water Solubility ]
Immiscible with water. | [Sensitive ]
Moisture Sensitive | [Detection Methods]
GC,NMR | [Merck ]
14,5139 | [BRN ]
956590 | [Dielectric constant]
9.2（20℃） | [Stability:]
Moisture Sensitive | [Uses]
Peptide reagent. | [CAS DataBase Reference]
543-27-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Isobutyl chloroformate(543-27-1) | [Storage Precautions]
Store under nitrogen;Moisture sensitive | [EPA Substance Registry System]
543-27-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
R10:Flammable.
R22:Harmful if swallowed.
R23:Toxic by inhalation.
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3390 6.1/PG 1
| [WGK Germany ]
2
| [F ]
10-19 | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
I | [HS Code ]
29159000 | [Toxicity]
LD50 orally in Rabbit: 1400 mg/kg |
| Hazard Information | Back Directory | [General Description]
A colorless to light-colored liquid. Insoluble in water and denser than water. Very corrosive to skin, eyes, and mucous membranes. Very toxic by ingestion, inhalation and skin absorption. Combustible. | [Reactivity Profile]
ISOBUTYL CHLOROFORMATE(543-27-1) is incompatible with water, with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. | [Air & Water Reactions]
Highly flammable. Insoluble in water. Reacts with moisture in the air to produce highly corrosive and toxic fumes of hydrogen chloride gas. Decomposes exothermically in water. | [Hazard]
Flammable. Corrosive. | [Health Hazard]
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Bromoacetates and chloroacetates are extremely irritating/lachrymators. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Potential Exposure]
This is a high volume chemical
with production exceeding 1 million pounds annually in the
U.S . No specific use found | [Fire Hazard]
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical attention. Rinse out mouth and do not induce vomiting.
Medical observation is recommended for 24 to 48 hours
after breathing overexposure, as pulmonary edema may be
delayed. Rest and medical observation is essential. As first
aid for pulmonary edema, a doctor or authorized paramedic
may consider administering a drug or other inhalation
therapy | [Shipping]
UN2742 Chloroformates, toxic, corrosive, flammable, n.o.s., Hazard class: 6.1; Labels: 6.1—Poison
Inhalation Hazard, 8—Corrosive material; 3—Flammable
liquid; Technical Name Required, Potential Inhalation
Hazard (Special Provision 5). PG II. UN3390 Toxic
by inhalation liquid, corrosive, n.o.s. with an LC50
# 1000 mL/m3 and saturated vapor concentration ≥ 10
LC50, Hazard Class: 6.1; Labels: 6.1—Poisonous materials,
8—Corrosive material, Technical Name Required,
Inhalation Hazard Zone B | [Incompatibilities]
Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides, alcohols, ethers, amines.
Forms explosive mixture with air above flash point
(27C). Compounds of the carboxyl group react with all
bases, both inorganic and organic (i.e., amines) releasing
substantial heat, water and a salt that may be harmful.
Incompatible with arsenic compounds (releases hydrogen
cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat,
toxic and possibly flammable gases), thiosulfates and
dithionites (releasing hydrogen sulfate and oxides of sulfur). Decomposes exothermically in water. Reacts with
moisture in air to produce highly corrosive and toxic
fumes of hydrogen chloride gas | [Chemical Properties]
A combustible, colorless to light-colored
liquid. | [Chemical Properties]
clear liquid | [Waste Disposal]
Disposal of unused product
must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate
protective equipment. For proper handling and disposal,
always comply with federal, state, and local regulations. | [reaction suitability]
reaction type: Coupling Reactions | [Purification Methods]
It can be dried over CaCl2 and fractionated at atmospheric pressure while keeping moisture out. Its purity can be checked by conversion to the phenyl urethane derivative with PhNCO [Saunders et al. J Am Chem Soc 73 3796 1951.] IR: 1780cm-1 [Thompson & Jameson Spectrochim Acta 13 236 1959, R.se JustusLiebigs Ann Chem 205 227 1880]. [Beilstein 3 IV 26.] |
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