成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

ChemicalBook--->CAS DataBase List--->54-11-5

54-11-5

54-11-5 Structure

54-11-5 Structure
IdentificationMore
[Name]

L-Nicotine
[CAS]

54-11-5
[Synonyms]

(-)-1-METHYL-2-[3-PYRIDYL]PYRROLIDINE
1-METHYL-2-(3-PYRIDYL)PYRROLIDINE
3-(1-METHYL-2-PYRROLIDINYL)PYRIDINE
3-(N-METHYL-2-PYRROLIDINYL)PYRIDINE
3-((S)-1-METHYL-PYRROLIDIN-2-YL)-PYRIDINE
BLACK LEAF 40
L-1-METHYL-2-[3-PYRIDYL]PYRROLIDINE
L(-)-NICOTINE
L-NICOTINE
NICO SOAP
(-)-NICOTINE
NICOTINE
NO-FID
S-(-)-NICOTINE
XL ALL NICOTINE
(-)-3-(1-Methyl-2-pyrrolidyl)pyridine
(-)-3-(N-Methylpyrrolidino)pyridine
(S)-3-(1-Methyl-2-pyrrolidinyl)pyridine
1-methyl-2-(3-pyridal)-pyrrolidin
1-Methyl-2-(3-pyridiyl)pyrrolidine
[EINECS(EC#)]

200-193-3
[Molecular Formula]

C10H14N2
[MDL Number]

MFCD00006369
[Molecular Weight]

162.23
[MOL File]

54-11-5.mol
Chemical PropertiesBack Directory
[Appearance]

Nicotine is a pale yellow to dark brown, oily liquid. Slight, fishy or pyridine-like odor when warm. It is also available as a powder.
[Melting point ]

-80 °C
[alpha ]

-166 º (c=neat)
[Boiling point ]

243-248 °C
[density ]

1.010 g/mL at 20 °C(lit.)
[vapor pressure ]

0.06 hPa (20 °C)
[refractive index ]

n20/D 1.5265(lit.)
[Fp ]

215 °F
[storage temp. ]

2-8°C
[solubility ]

ethanol: 50 mg/mL
[form ]

liquid
[pka]

8.02(at 25℃)
[color ]

yellow
[PH]

10.2 (8.1g/l, H2O, 20°C)
[explosive limit]

0.7-4%(V)
[Odor Threshold]

0.011ppm
[optical activity]

[α]20/D 169°(lit.)
[Water Solubility ]

MISCIBLE
[Sensitive ]

Air Sensitive & Hygroscopic
[Usage]

Naturally-occuring isomer
[Merck ]

14,6524
[BRN ]

82109
[Exposure limits]

TLV-TWA air 0.5 mg/m3 (ACGIH, MSHA, and OSHA).
[LogP]

1.170
[CAS DataBase Reference]

54-11-5(CAS DataBase Reference)
[NIST Chemistry Reference]

3-(2-(N-methylpyrrolidinyl))pyridine(54-11-5)
[EPA Substance Registry System]

54-11-5(EPA Substance)
Questions And AnswerBack Directory
[alkaloid]

Nicotine is the substance in tobacco, nicotine content of tobacco because there are different species and origin, alkali content of tobacco each part is different. Cigarette factory scraps (tobacco powder) containing about 1% to 2% of the nicotine, tobacco stems and ribs smoke nicotine containing about 1% or so, people smoked cigarette contains nicotine amounted to about 3%. Pure nicotine is a colorless, oily liquid, miscible with water below 60 ℃, hydrate, more than 210 ℃ also miscible with water. Unstable nature, likely to be volatile, soluble in water and organic solvents. Nicotine is an alkaloid, so all properties of a base, to a compound made of salts and acids. In case of light and air turn brown and sticky, there is the odd smell and strong irritant.
[Toxicity]

Pure nicotine for people, livestock highly toxic rat oral LD50 of 50~60mg/kg, rabbit acute percutaneous LD5050mg/kg. Rabbit acute percutaneous LD50 for 50~60mg/kg, rabbit acute oral LD50 of 50mg/kg. Based on China's pesticide toxicity grading standards, is a highly toxic pesticides. However, because of volatile and rapidly decompose in air and light, and therefore can still be used to control pests on crops. Rapidly absorbed through the skin, inhalation and dermal exposure to toxic people. Toxic to birds. Young steelhead LC504mg/L, toxic to bees, but there insecticide effect. D. Pulex LC50 of 0.24mg/L. Fish and shellfish toxicity, mild injury to crops.
Safety DataBack Directory
[Hazard Codes ]

T+,N,Xn,F,Xi
[Risk Statements ]

R25:Toxic if swallowed.
R27:Very Toxic in contact with skin.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36:Irritating to the eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin .
[Safety Statements ]

S7:Keep container tightly closed .
S16:Keep away from sources of ignition-No smoking .
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
[RIDADR ]

UN 1654 6.1/PG 2
[WGK Germany ]

3
[RTECS ]

QS5250000
[Autoignition Temperature]

240 °C
[TSCA ]

Yes
[HazardClass ]

6.1
[PackingGroup ]

II
[HS Code ]

29399910
[Hazardous Substances Data]

54-11-5(Hazardous Substances Data)
[IDLA]

5 mg/m3
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Calcium hydroxide-->calcium sulfate
[Preparation Products]

Nicotinic acid-->NORNICOTINE, DL-(RG)-->3-(4,5-DIHYDRO-1-METHYL-1H-PYRROL-2-YL)PYRIDINE-->(+/-)-NICOTINE
Hazard InformationBack Directory
[General Description]

Liquids. Toxic by inhalation, ingestion, and skin absorption. More dense than water. Flash points usually below 140°F. Contact may irritate skin, eyes, and mucous membranes. If available, obtain the technical name of the material from the shipping papers and contact CHEMTREC, (800-424-9300) for specific response information.
[Reactivity Profile]

An alkaloid produced from tobacco. Colorless, oily liquid, combustible, highly toxic. When heated to decomposition (-)-NICOTINE(54-11-5) emits very toxic fumes of carbon monoxide and oxides of nitrogen [Lewis, 3rd ed., 1993, p. 919].
[Air & Water Reactions]

Flammable. Slightly soluble in water.
[Hazard]

Toxic by ingestion, inhalation, and skin absorption. Gastrointestinal damage, central nervous system impairment, and cardiac impairment
[Health Hazard]

(-)-NICOTINE is classified as super toxic. Probable oral lethal dose in humans is less than 5 mg/kg or a taste (less than 7 drops) for a 70 kg (150 lbs.) person. It may be assumed that ingestion of 40-60 mg of nicotine is lethal to humans. There is fundamental difference between acute toxicity from use of nicotine as insecticide or from ingestion, and chronic toxicity that may be caused by prolonged exposure to small doses as occurs in smoking. Maternal smoking during pregnancy is associated with increased risk of spontaneous abortion, low birth weight and still-birth. Nicotine was found as a co-carcinogen in animals.
[Potential Exposure]

An alkaloid produced from tobacco. Nicotine is used in some drugs; and in tanning. At one time, nicotine was used in the United States as an insecticide and fumigant; however, it is no longer produced or used in the United States for this purpose.
[Fire Hazard]

There is a moderate explosion hazard when exposed to heat or flame. When heated to decomposition, (-)-NICOTINE emits nitrogen oxides, carbon monoxide and other highly toxic fumes. Avoid oxidizing materials. Stable under normal conditions. Avoid heat or flames.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
[Shipping]

UN1654 Nicotine, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
[Incompatibilities]

Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Incompatible with strong acids. Attacks some forms of plastics, rubber, and coatings.
[Description]

(–)-Nicotine is an alkaloid that has been found in tobacco. It is an agonist at neuronal nicotinic acetylcholine receptors (nAChRs) and binds to α3β4 and α4β2 subunit-containing nAChRs with Ki values of 481 and 11.1 nM, respectively. Chronic exposure to (–)-nicotine results in increased expression of certain nAChRs, particularly α4β2 subunit-containing nAChRs. (–)-Nicotine has addictive properties. Formulations containing (–)-nicotine have been used as smoking cessation aids for the relief of nicotine withdrawal symptoms.
[Description]

Nicotine is an alkaloid obtained from the dried leaves of Nicotiana tabacum and Nicotiana rustica. Nicotine stimulates acetylcholine receptors of the postsynaptic membrane at nerve synapses resulting in depolarization of the membrane. Toxic doses cause stimulation that is rapidly followed by blockade of nerve transmission.
[Chemical Properties]

Nicotine is a pale yellow to dark brown, oily liquid. Slight, fishy or pyridine-like odor when warm. It is also available as a powder.
[Chemical Properties]

Yellow Liquid
[Waste Disposal]

Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal.
[Originator]

Nicotinell TTS,Novartis
[Uses]

(S)-(-)-Nicotine is a prototype nicotinic acetylcholine receptor agonist. (S)-(-)-Nicotine is the naturally occurring isomer. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.
[Uses]

Naturally-occuring isomer
[Uses]

Nicotine is one of the principal constituentsof tobacco. It occurs in the dried leavesof Nicotiana tabacum and Nicotiana rusticato the extent of 2–8%. Exposure risk tothis alkaloid arises from smoking, chewing,or inhaling tobacco. Nicotine and its saltsare used as insecticides and fumigants, intanning, and in medicine.
[Uses]

Nicotine is the second most widely used recreational drug after caffeine. At low doses, nicotineacts as a stimulant to the central nervous system by activating acetylcholine receptors, specifically called nicotinic acetylcholine receptors, in the postsynaptic neurons during nerve transmission.At higher doses nicotine acts as a depressant.Nicotine in tobacco has always been used for medicinal purposes. Nicotine solutions made from soaking tobacco leaves in water have been used as pesticides for several hundred years. In modern times, numerous pharmaceutical companies have explored nicotine's use for treating diseases. Nicotine's most prevalent medicinal use is for smoking cessation in the form of alternate delivery systems such as gums and dermal patches. Nicotine is used medically for numerous conditions and its use is being explored in additional areas including pain relievers, attention deficit disorder medications and medications associated with Alzheimer's disease, Parkinson disease, colitis, herpes, and tuberculosis.
[Uses]

Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
[Definition]

A colourless poisonousalkaloid present in tobacco. It isused as an insecticide.
[Definition]

ChEBI: An optically active form of nicotine having S-configuration.
[Production Methods]

The nicotine molecule consists of a pyrrolidine ring attached to a pyridine ring by a bondbetween carbon atoms in the two-ring systems. Nicotine was isolated in impure form fromtobacco in 1809 by Louis Nicholas-Vauquelin (1763–1829). Vauquelin called the substancenicotianine. In 1826, Wilhelm Posselt (1806–1877) and Karl Ludwig Reimann (1804–1872),medical students at Heidelberg University, isolated pure nicotine and published dissertationson its pharmacology in 1828. Louis Henri Melsens (1814–1886) determined nicotine’sempirical formula. Amé Pictet (1857–1937) and P. Crépieux reported the synthesis of nicotine in 1903.
[Manufacturing Process]

The water extract from Nicotiana tabacum was prepared by distillation of nicotine contained liquor from tobacco leaves, as described in D.R. Patent No. 319,846; September 12, 1913.
5 kg this water extract or the same quantity of tobacco powder in water was mixed with 1.5 kg of grinded calcium hydroxide and 1.5 kg calcium sulfate. The mixture stood for 24 hours. The obtained mixture looked like a dry powder. It was extracted with ether. The ether was distilled and the residue contented 98% of clear nicotine - liquid with odor of pyridine; BP: 246C/735 mm; d4 20 =1.0097; [α]d 20=- 166.5.
[Brand name]

Habitrol (Novartis); Nicoderm (Sanofi Aventis); Nicotrol (Pharmacia & Upjohn); Prostep (Aveva).
[Therapeutic Function]

Ganglion depressant, Smoking deterrent
[Agricultural Uses]

Insecticide: Nicotine is used in some drugs and insecticides. Classified for restricted use as an insecticide, limited to use by or under the direct supervision of a certified applicator. Not listed for use in EU countries. Registered for use in the U.S. and Canada. A U.S. EPA restricted Use Pesticide (RUP).
[Trade name]

BLACK LEAF®; CAMPBELL'S NICOSOAP ®; DESTRUXOL ORCHARD SPRAY®; EMONIB ®; FLUX MAAG®; FUMETO-TENDUST®; BAC®; MACH-NIC®; NIAGARA P. A. DUST®; NICODUST®; NICOFUME®; NICOCIDE®; ORTHO N-4 DUST®; XL ALL INSECTICIDE®
[Carcinogenicity]

Nicotine has low carcinogenic potential. One study found that diets containing 60 ppm nicotine and administered to rats for 300 days reduced the growth rate. The authors concluded that reduced body weight gains were only partially attributable to reduced food intake. No pathology on the rats and no evidence of carcinogenicity were reported. Rats were injected subcutaneously (5 days/week) for 26 weeks followed by an approximate 2-month observation period. Similarly, dogs were injected subcutaneously (5 days/week) for the same period. No tumors were observed in the test animals, although hyaline thickening and fibrosis of the vasculature of the kidney, lung, brain, and heart were evident.
[Metabolic pathway]

Nicotine has been used as an insecticide for at least 200 years but this naturally occurring compound lacks persistence and can be hazardous in use (Corbett et al., 1984). It has been replaced with more effective synthetic insecticides such as those in the neonicotinoid class. Most of the mformation on metabolism derives from research into the fate of nicotine after tobacco smoking as well as from the use of nicotine in agriculture and horticulture or through the biosynthesis of the alkaloid by plants and vegetables used as normal foodstuffs. Up to eight metabolites have been isolated and identified in man with six primary pathways. The main pathway is N-carbon oxidation of the pyrrolidine ring to form cotinine, others being N-oxidation of the pyrrolidine ring to form nicotine N-oxide, N-methylation of the pyridine ring to form an N-methylnicotinium ion and N-demethylation of the pyrrolidine ring to form nornicotine. Two other pathways are formation of a nicotine enamhe and of a nicotine glucuronide (Gabrielsson and Gumbleton, 1993). There is little information on the fate of nicotine in soil.
[Metabolism]

Nicotine is well absorbed from the mucous membranes in the oral cavity, gastrointestinal tract, and respiratory system. If tobacco smoke is held in the mouth for 2 seconds, 66 to 77% of the nicotine in the smoke will be absorbed across the oral mucosa. If tobacco smoke is inhaled, approximately 90 to 98% of the nicotine will be absorbed. Nicotine is distributed throughout the body, readily crossing the blood-brain and placental barriers. The liver, kidney, and lung metabolize approximately 80 to 90% of the alkaloid. The kidney rapidly eliminates nicotine and its metabolites.
[Purification Methods]

(-)-Nicotine is a very pale yellow hygroscopic oil with a characteristic odour (tobacco extract) which turns brown in air on exposure to light. It is purifed by fractional distillation under reduced pressure in an inert atmosphere. A freshly distilled sample should be stored in dark sealed containers under N2. It is a strong base; a 0.05 M aqueous solution has a pH of 10.2. It is very soluble in organic solvents. It is soluble in H2O and readily forms salts. [UV: Parvis J Chem Soc 97 1035 1910, Dobbie & Fox J Chem Soc 103 1194 1913.] The hydrochlorides (mono-and di-) form deliquescent crystals soluble in H2O and EtOH but insoluble in Et2O. It has also been purified via the ZnCl2 double salt. [Ratz Monatsh Chem 26 1241 1905, Biosynthesis: Nakan & Hitchinson J Org Chem 43 3922 1978.] The picrate has m 218o (from EtOH). [Beilstein 23/6 V 64.] POISONOUS.
[Degradation]

Nicotine is volatile and decomposes relatively quickly under the influence of light and air. The pyrrolidine nitrogen (pka 8.2) is more basic than the pyridine moiety (pka 3.1) (PM). Nicotine has a chiral centre, and exists naturally as the more potent (S) enantiomer.
[References]

Pictet, Rotschy., Ber., 33, 2533 (1900)
Tschitschibabin, Buchholz.,J. Russ. Phys. Chern. Soc., 50, 548 (1920)
Spath, Biniecki., Ber., 72, 1809 (1939)
Shmuk, Borozdina., CampI. rend. Acad. Sci., USSR, 12,1582 (1939)
Shmuk, Borozdina., J. Appl. Chern. Russ., 14,864 (1941)
Smith, Smith., J. Agric. Res., 65, 347 (1942)
Pal, Narasinham.,!. Ind. Chern. Soc., 20, 181 (1943)
Marion., Can. J. Res., 23B, 165 (1945)
Bottomley, Nottle, White., Austral. J. Sci., 8, 18 (1945)
Biosynthesis: Leete.,!. Amer. Chern. Soc., 89,7081 (1967)
14C-NMR spectrum: Ganz, Kelsey, Geiling., Bot. Gaz., 113, 195 (1951)
13C-NMR spectrum: Crain, Wilderman, Roberts., J. Amer. Chern. Soc., 93,990 (1971)
Pharmacology : Rolleston., Lancet., 210,961 (1926)
Laessing., Med. Welt., 12, 1485 (1938)
Coon, Rothman., Proc. Soc. Exp. Bioi. Med., 42, 231 (1939)
Straub, Amann., Klin. Woch., 19,169 (1940)
Coon, Rothman., J. Pharm. Exp. Ther. Froc., 72, 9 (1941)
Perlman, Dannesborg, Sokoloff., J. Amer. Med. Assoc., 120, 1003 (1942)
Roth, McDonald, Sheard., ibid, 125,761 (1944)
Burn, Truelove, Burn., Brit. Med. J., i, 403 (1945)
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Nicotine(54-11-5).msds
Spectrum DetailBack Directory
[Spectrum Detail]

Nicotine(54-11-5)MS
Nicotine(54-11-5)1HNMR
Nicotine(54-11-5)13CNMR
Nicotine(54-11-5)IR1
Nicotine(54-11-5)Raman
Tags:54-11-5 Related Product Information
123-75-1 110-86-1 5380-42-7 96-33-3 143390-89-0 99-76-3 1746-01-6 298-00-0 22083-74-5 3222-47-7 2942-59-8 498-94-2 10177-29-4 98-92-0 5470-70-2 84358-13-4 59-67-6 74-83-9