| Identification | More | [Name]
tert-Butyl bromoacetate | [CAS]
5292-43-3 | [Synonyms]
2-BROMOACETIC ACID-TERT-BUTYL ESTER
BROMOACETIC ACID TERT-BUTYL ESTER
BUTYLBROMOACETATE-TERT
T-BUTYL 2-BROMOACETATE
T-BUTYL BROMOACETATE
TERT-BUTYL 2-BROMOACETATE
TERT-BUTYL BROMOACETATE
1-Butylbromoacetate
Acetic acid, bromo-, tert-butyl ester
aceticacid,bromo-,1,1-dimethylethylester
BrCH2C(O)OC(CH3)3
bromoacetic acid T-butyl ester
tertiary butyl bromoacetate
2-Bromoacetic acid-t-butylester
#ntert.-Butyl bromoacetate
tert-Butylbromoacetate,98%
tert-Butyl bromoacetate 98%
2-BROMOACETICACIDTERT-BUTYLESTER(TERT-BUTYLBROMOACETATE)
tert-Butyl bromoacetate, 99 %
1,1-Dimethylethyl 2-bromoacetate | [EINECS(EC#)]
226-133-6 | [Molecular Formula]
C6H11BrO2 | [MDL Number]
MFCD00000188 | [Molecular Weight]
195.05 | [MOL File]
5292-43-3.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless to yellow liquid | [Melting point ]
44-47 °C | [Boiling point ]
50 °C10 mm Hg(lit.)
| [density ]
1.338 | [vapor pressure ]
1.62hPa at 25℃ | [refractive index ]
n20/D 1.445(lit.)
| [Fp ]
121 °F
| [storage temp. ]
0-6°C
| [solubility ]
Chloroform, Ethyl Acetate (Slightly) | [form ]
Liquid | [color ]
Clear colorless to yellow | [Specific Gravity]
1.333 (20/4℃) | [Water Solubility ]
Miscible with ethanol, chloroform and ethyl acetate. Immiscible with water. | [Sensitive ]
Lachrymatory | [Detection Methods]
GC,NMR | [BRN ]
1753010 | [InChIKey]
BNWCETAHAJSBFG-UHFFFAOYSA-N | [CAS DataBase Reference]
5292-43-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Acetic acid, bromo-, 1,1-dimethylethyl ester(5292-43-3) | [EPA Substance Registry System]
5292-43-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,F | [Risk Statements ]
R10:Flammable.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S24/25:Avoid contact with skin and eyes .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [F ]
19 | [Hazard Note ]
Irritant/Flammable/Lachrymatory | [TSCA ]
T | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29159080 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless to yellow liquid | [Uses]
tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors. | [Uses]
tert-Butyl bromoacetate is used as an intermediate in the production of dyes, pharmaceuticals, agrochemicals and in organic compounds. It finds application as an alkylating agent. It plays an important role to prepare (2-oxo-4-vinyl-azetidin-1-yl)-acetic acid tert-butyl ester and in collagenase inhibitors synthesis. | [Application]
tert-Butyl bromoacetate has been used in the synthesis of:
nitrilotriacetic acid end-functionalized polystyrene by atom transfer radical polymerization
building block for substituted t-butyl acetates
dihydropyranyl prelinker which is useful in polymer-assisted deprotection of oligosacchararides
collagenase inhibitor (S,S,R)-(-)-actinonin It is the starting reagent for the synthesis of N-Oxalylglycine derivatives. | [Preparation]
Tert-butyl bromoacetate ester was synthesized using bromoacetic acid and isobutylene as raw materials,Amberlyst 15,a strong acidic cation exchange resin,as catalyst,and tert-butanol as modifier. | [General Description]
tert-Butyl bromoacetate serves as building blocks during the synthesis of model N-substituted oligoglycines (peptoids) containing an N-linked lactoside side-chain. | [Flammability and Explosibility]
Flammable | [Safety]
Tert-Butyl bromoacetate is a lachrymator. The reagent, reaction and its work-up should be handled in an adequately ventilated fume hood while wearing gloves, safety glasses and laboratory coat.
| [Purification Methods]
Dissolve the ester in Et2O, wash it well with ice cold 10% aqueous K2CO3, dry it over CaCl2, filter and evaporate the Et2O, then fractionate it through a Vigreux column (p 11) in a vacuum. LACHRYMATORY. [Abramovitch et al. J Am Chem Soc 64 2274 1942, Abramovitch & Hauser J Am Chem Soc 65 986 1943, Beilstein 2 III 482.] |
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