| Identification | More | [Name]
Fluorescein disodium salt | [CAS]
518-47-8 | [Synonyms]
ACID YELLOW 73
CALCOCID URANINE B-4315
CI 45350
CI NO 45350
D AND C YELLOW NO 8
FLUORESCEIN DISODIUM
FLUORESCEIN DISODIUM SALT
FLUORESCEIN DISODIUM SALT HYDRATE
FLUORESCEIN SODIUM
FLUORESCEIN, SODIUM DERIVATIVE, SODIUM SALT
FLUORESCEIN SODIUM SALT
FLUORESCEIN, WATER SOLUBLE
HIDACID URANINE
S NO 880
SODIUM FLUORESCEIN
URANIN
URANINE
URANINE AP
URANINE SS
URANINE, WATER SOLUBLE | [EINECS(EC#)]
208-253-0 | [Molecular Formula]
C20H10Na2O5 | [MDL Number]
MFCD00167039 | [Molecular Weight]
376.27 | [MOL File]
518-47-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Orange-red powder; odorless. Hygroscopic,
soluble in water; sparingly soluble in
alcohol. | [Melting point ]
320 °C
| [density ]
0.579[at 20℃] | [vapor pressure ]
2.133hPa | [storage temp. ]
Store at +5°C to +30°C. | [solubility ]
H2O: soluble1mg/mL | [Colour Index ]
45350 | [form ]
Powder | [pka]
2.2, 4.4, 6.7(at 25℃) | [color ]
Rust-orange | [Odor]
Odorless | [PH]
8.3 (10g/l, H2O, 20℃) | [PH Range]
Pink uorescence (4.0) to green uorescence (6.0) | [Stability:]
Stable. | [Water Solubility ]
500 g/L (20 ºC) | [λmax]
491nm, 493.5nm, 490nm | [Merck ]
14,4159 | [BRN ]
3833041 | [Major Application]
Nanolithography, nanoparticles, thin films, fuel cells, inks, laser, colored bubbles, cleansing products, identifying leaks in coolant, suntanning agent, hair dyes, cosmetics, dermatology, dental material, diagnosis of diabetic retinopathy, antitumor agent | [InChIKey]
NJDNXYGOVLYJHP-UHFFFAOYSA-L | [LogP]
0.34 | [CAS DataBase Reference]
518-47-8(CAS DataBase Reference) | [EPA Substance Registry System]
518-47-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36:Irritating to the eyes.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes .
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S27:Take off immediately all contaminated clothing . | [WGK Germany ]
1
| [RTECS ]
LM5425000
| [F ]
3 | [TSCA ]
Yes | [HS Code ]
32041200 | [Safety Profile]
Moderately toxic by
intraperitoneal route. Mildly toxic by
ingestion. Human systemic effects by
intravenous route: arrhythmias, eye
hemorrhage, nausea or vomiting.
Experimental reproductive effects.
Questionable carcinogen with experimental
tumorigenic data. Mutation data reported.
When heated to decomposition it emits
toxic fumes of Na2O. | [Hazardous Substances Data]
518-47-8(Hazardous Substances Data) | [Toxicity]
LD50 in mice, rats (mg/kg): 4738, 6721 orally (Yankel, Loux) |
| Hazard Information | Back Directory | [General Description]
Orange-red to dark red powder. Water-soluble form of fluorescein. Odorless and almost tasteless. pH (5% solution) 7.8. May be sensitive to prolonged exposure to light and to heat. | [Reactivity Profile]
FLUORESCEIN, DISODIUM SALT(518-47-8) is incompatible with strong oxidizers. Also incompatible with acids, acid salts and salts of heavy metals . | [Air & Water Reactions]
Hygroscopic. Water soluble. | [Fire Hazard]
Flash point data for this chemical are not available; however, FLUORESCEIN, DISODIUM SALT is probably combustible. | [Chemical Properties]
Orange-red powder; odorless. Hygroscopic,
soluble in water; sparingly soluble in
alcohol. | [Uses]
A sodium salt of fluorescein | [Uses]
In examining subterranean waters. Serves to ascertain source of springs, connections between streams and sea, determining approx vol of water delivered by a spring, detecting source of contamination of drinking water, infiltration of soil with waste waters of factories. In externally applied drugs and cosmetics. Analytical reagent (protein label). Clinical reagent (immuno-histological stain, immuno-fluorescent label). | [Veterinary Drugs and Treatments]
Fluorescein sodium is a yellow water-soluble dye that fluoresces
under a Wood’s Lamp, but is plainly visible after binding to corneal
stroma through an ophthalmic examination light source. It is
used most commonly to delineate full thickness loss of corneal epithelium
indicating the presence of a corneal ulceration. In this instance
it will stain the corneal stroma. The epithelium is not stained
because its outer lipid cell membrane repels the stain. Descemet’s
membrane will not stain with fluorescein stain and this is used to
indicate descemetocele formation, an ocular emergency.
Fluorescein stain is applied to the precorneal tear film in dogs
and cats and the break-up of this stain with time, as observed
through a slit lamp biomicroscope using a cobalt blue light source,
is used to determine the tear film break-up time (normal 19 seconds),
an indicator of tear film quality.
Fluorescein stain is applied to the tear film of dogs to determine
patency of the nasolacrimal outflow system. The normal wait time
is 2 – 5 minutes in dogs and up to 10 minutes in cats. A positive test
indicates patency of the system. A negative test is not indicative of
disease as the test is negative in a large percentage of normal animals.
Fluorescein stain, then, can be added to irrigating solution to
flush the nasolacrimal system, making detecting the irrigation solution
at the nose more obvious during flushing of the system. | [Properties and Applications]
brilliant yellow. Soluble in water and ethanol (with strong green fluorescent), water-soluble good. In strong sulfuric acid with weak for fluorescence yellow, it will be diluted with yellow precipitation. Its water solution and sodium hydroxide with dark green fluorescence for brunet solution. Mainly used for sea of target that fluorescent, facilitate aerial reconnaissance search. And can use significantly for the exploration of fluorescent groundwater. Can also be used for medicine and cosmetics shading, rarely used for silk printing and dyeing things. |
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