| Identification | More | [Name]
Tioxolone | [CAS]
4991-65-5 | [Synonyms]
6-HYDROXY-1,3-BENZOXANTHIOL-2-ONE
6-HYDROXY-1,3-BENZOXATHIOL-2-ONE
THIOXOLONE
TIOXOLONE
1,3-Benzoxathiol-2-one, 6-hydroxy-
6-hydroxy-3-benzoxathiol-2-one
acnosan(antiseborrheic)
Camyna
component of Psoil
ol110
Stepin
thidoxol
Thioxalone
thioxolon
Thiphen
tioxolon
Trocinate
6-HYDROXY-1,3-BENZOXATHIOL-2-ONE, 98+%
6-Hydroxy-2-oxo-1,3-benzoxathiole
6-Hydroxy-2-oxobenzoxathiole | [EINECS(EC#)]
225-653-0 | [Molecular Formula]
C7H4O3S | [MDL Number]
MFCD00005859 | [Molecular Weight]
168.17 | [MOL File]
4991-65-5.mol |
| Chemical Properties | Back Directory | [Appearance]
light yellow to beige powder | [Melting point ]
158-160 °C(lit.) | [Boiling point ]
267.1°C (rough estimate) | [density ]
1.4844 (rough estimate) | [refractive index ]
1.5151 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow | [form ]
A solid | [pka]
8.14±0.20(Predicted) | [color ]
Light yellow to yellow | [Water Solubility ]
95% ethanol: soluble 50mg/mL, clear to very slightly hazy, colorless to yellow
benzene: soluble
diethyl ether: soluble
isopropanol: soluble
propylene glycol: soluble
toluene: soluble
water: insoluble | [Merck ]
9456 | [LogP]
1.770 (est) | [CAS DataBase Reference]
4991-65-5(CAS DataBase Reference) | [NIST Chemistry Reference]
Tioxolone(4991-65-5) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
DM2953750
| [HS Code ]
2934999090 |
| Hazard Information | Back Directory | [Chemical Properties]
light yellow to beige powder | [Originator]
Acnosan,Unia | [Uses]
6-Hydroxy-1,3-benzoxathiol-2-one was used in the synthesis of heterocycle-phosphor esters having potential antimicrobial activity. | [Uses]
antiseborrhoic | [Definition]
ChEBI: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position. | [Manufacturing Process]
40 g potassium thiocyanate in 50 ml of water are added, while stirring at
room temperature, to a solution of 11 g of resorcinol and 50 g of crystallized
copper sulfate in 250 ml of water. The black cupric thiocyanate formed
becomes colorless after a short time, which indicates that the introduction of
thiocyanogen is terminated. The cuprous thiocyanate is removed by filtering
with suction and then washed with water; the filtrate is mixed with 50 ml of a
2 N sodium carbonate solution, whereby the imino-thiocarbonate of resorcinol
separates in the form of a colorless crystalline body. The yield amounts to 16
g. The new compound which melts at 149°C dissolves very easily in many
organic solvents and in mineral acids.
A 10% solution of the imino-thiocarbonate of resorcinol in 10% hydrochloric
acid is heated for 15 min on the steam bath. The 6-hydroxy-1,3-benzoxathiol-
2-one (thiocarbonate free from) nitrogen separates, on cooling, in the form of
fine crystals melting at 158°C. | [Therapeutic Function]
Antiseborreic, Antifungal, Keratolytic | [General Description]
Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one has been investigated. Supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one has been studied. | [storage]
Store at -20°C |
|
|