| Identification | More | [Name]
DL-Homocysteine | [CAS]
454-29-5 | [Synonyms]
2-AMINO-4-MERCAPTOBUTYRIC ACID
2-AMINO-4-MERCAPTOBUYRIC ACID
DL-HOMOCYSTEINE
HOMOCYSTEINE, DL-
(+-)-homocysteine
dl-2-amino-4-mercaptobutyricacid
usafb-12
DL-Homocysteine 2-Amino-4-mercaptobuyric acid
2-amino-4-sulfanylbutanoic acid
HOMOCYSTEINE, DL-(RG)
TOTALHOMOCYSTEINE
H-DL-Hcys-OH | [EINECS(EC#)]
207-222-9 | [Molecular Formula]
C4H9NO2S | [MDL Number]
MFCD00004898 | [Molecular Weight]
135.18 | [MOL File]
454-29-5.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
232-233 °C(lit.) | [Boiling point ]
299.7±35.0 °C(Predicted) | [density ]
1.149 (estimate) | [refractive index ]
1.5480 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
H2O: soluble | [form ]
solid | [pka]
2.22, 8.87, 10.86(at 25℃) | [color ]
White to Off-White | [Stability:]
Stable. Combustible. Incompatible with strong oxidizing agents. | [optical activity]
[α]/D 0±1°, c = 1 in H2O | [Merck ]
4734 | [BRN ]
1721683 | [InChIKey]
FFFHZYDWPBMWHY-UHFFFAOYSA-N | [LogP]
0.220 (est) | [CAS DataBase Reference]
454-29-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
MT0175000
| [F ]
10-23 | [HS Code ]
29309090 | [Toxicity]
LD50 intraperitoneal in mouse: 500mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
DL-Homocysteine has been used to induce hyperhomocysteinemia in Sprague–Dawley rats. It has also been used to study the effects of hyperhomocysteinemia on atherosclerosis in apolipoprotein E-deficient mice. | [Definition]
ChEBI: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain. | [Biochem/physiol Actions]
Homocysteine is a sulfhydryl-containing amino acid, synthesized from methionine. It is a non-essential, non-proteinogenic amino acid. It is an important determinant of the methylation cycle and is present in the plasma in four forms. An abnormally high level of homocysteine leads to hyperhomocysteinemia and also promotes atherosclerosis. | [storage]
Store at -20°C | [Purification Methods]
Purify it as for the L-isomer. [Allen & Steinmann J Am Chem Soc 74 3932 1952, and references for the L-isomer above, Beilstein 4 IV 3189.] |
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