| Identification | More | [Name]
L-ETHIONINE | [CAS]
13073-35-3 | [Synonyms]
H-ETH-OH
L-2-AMINO-4-(ETHYLTHIO)BUTYRIC ACID
L-ETHIONINE
2-amino-4-(ethylthio)-butanoicaci
alpha-amino-gamma-(ethylmercapto)butyricacid
homocysteines-ethylether
l-butyricaci
s-ethyl-homocystein
s-ethyl-l-homocystein
S-ethyl-L-homocysteine
L-ETHIONINE 99%
L-ETHIONINE 98+%
(S)-2-Amino-4-(ethylthio)butyric acid
[S,(+)]-2-Amino-4-(ethylthio)butyric acid | [EINECS(EC#)]
235-966-4 | [Molecular Formula]
C6H13NO2S | [MDL Number]
MFCD00002626 | [Molecular Weight]
163.24 | [MOL File]
13073-35-3.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
280 °C (dec.)(lit.) | [alpha ]
D24 +25.1°; D23 +20.1° (1N HCl) (Armstrong, Lewis) | [density ]
1.085 (estimate) | [refractive index ]
22 ° (C=1, 1mol/L HCl) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
Aqueous Acid (Slightly), Water (Slightly) | [Boiling point ]
310.4±37.0 °C(Predicted) | [form ]
solid | [pka]
2.23±0.10(Predicted) | [color ]
White to Off-White | [Merck ]
3738 | [CAS DataBase Reference]
13073-35-3(CAS DataBase Reference) | [EPA Substance Registry System]
L-Ethionine (13073-35-3) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
ES6825300
| [HS Code ]
2930.90.4950 | [Hazardous Substances Data]
13073-35-3(Hazardous Substances Data) | [Toxicity]
rat,LD,intraperitoneal,> 1gm/kg (1000mg/kg),LIVER: OTHER CHANGESLIVER: CHANGES IN LIVER WEIGHT,Acta Pathologica Japonica. Vol. 39, Pg. 281, 1989. |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Ethionine-induced inhibition of protein synthesis and lowering of ATP level in the liver. | [Definition]
ChEBI: An S-ethylhomocysteine that has S-configuration at the chiral centre. | [Biological Activity]
An analog of methionine th at interferes with the normal methylation of DNA and other methylation pathwaysand induces pancreatic toxicity and liver cancer. Howeverin animal studiesit has also been shown to act synergistically with methionine-depletion to block the growth and metastasis of methionine-dependent tumors. | [Purification Methods]
Likely impurities are N-acetyl-(R and S)-ethionine, S-methionine, and R-ethionine. Crystallise it from water by adding 4volumes of EtOH or 85% aqueous EtOH. It sublimes at 196-216o/0.3mm with 99.1% recovery and unracemised [Gross & Gradsky J Am Chem Soc 77 1678 1955]. [Weiss & Stekol J Am Chem Soc 73 2399 1951, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2658, 2659 1961, Beilstein 4 IV 3194.] |
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