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ChemicalBook--->CAS DataBase List--->370-86-5

370-86-5

370-86-5 Structure

370-86-5 Structure
IdentificationBack Directory
[Name]

FCCP
[CAS]

370-86-5
[Synonyms]

FCCP
FCCCP
p-CF3O-CCP
4-(TRIFLUOROMETHOXY)PHENYLAZOMALONONITRILE
CARBONOYLCYANID-4-TRIFLUORMETHOXYPHENYL-HYDRAZON
Trifluoromethoxy carbonylcyanide phenylhydrazone
Carbonylcyanide-p-trifluoromethoxuphenylhydrazone
MESOXALONITRILE 4-TRIFLUOROMETHOXYPHENYLHYDRAZONE
CARBONYL CYANIDE 4-TRIFLUOROMETHOXYPHENYLHYDRAZONE
CARBONYL CYANIDE P-TRIFLUOROMETHYL PHENYLHYDRAZONE
CARBONYL CYANIDE P-(TRIFLUOROMETHOXY)PHE NYLHYDRAZO
[[4-(trifluoromethoxy)phenyl]hydrazono]malononitrile
mesoxalonitrile,(p-(trifluoromethoxy)phenyl)hydrazone
CARBONYL CYANIDE P-(TRI-FLUOROMETHOXY)PHENYL-HYDRAZONE
2-[4-(Trifluoromethoxy)phenyl]hydrazonopropanedinitrile
((4-(trifluoromethoxy)phenyl)hydrazono)-propanedinitril
2-[2-[4-(TRIFLUOROMETHOXY)PHENYL]HYDRAZONO]MALONONITRILE
FCCP, Mesoxalonitrile 4-trifluoromethoxyphenylhydrazone
Propanedinitrile, [[4-(trifluoromethoxy)phenyl]hydrazono]-
2-[[4-(trifluoromethoxy)phenyl]hydrazinylidene]propanedinitrile
2-[2-[4-(Trifluoromethoxy)phenyl]hydrazinylidene]propanedinitrile
Propanedinitrile, 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-
{2-[4-(Trifluoromethoxy)phenyl]hydrazinylidene}propane-1,3-dinitrile, 4-[2-(Dicyanomethylidene)hydrazino]-alpha,alpha,alpha-trifluoroanisole
[EINECS(EC#)]

206-730-8
[Molecular Formula]

C10H5F3N4O
[MDL Number]

MFCD00009699
[MOL File]

370-86-5.mol
[Molecular Weight]

254.17
Chemical PropertiesBack Directory
[Melting point ]

174-175 °C (dec.)(lit.)
[Boiling point ]

293.3±50.0 °C(Predicted)
[density ]

1.34±0.1 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

acetone: 20 mg/mL, clear, very deep greenish yellow
[form ]

powder
[pka]

5.91±0.10(Predicted)
[color ]

yellow
[BRN ]

664446
[Stability:]

Stable for 2 years from date of purchase as supplied. Protect from exposure to moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
[CAS DataBase Reference]

370-86-5
Safety DataBack Directory
[Hazard Codes ]

T,Xi
[Risk Statements ]

25-43
[Safety Statements ]

36/37-45
[RIDADR ]

UN 2811 6.1/PG 2
[WGK Germany ]

3
[RTECS ]

FG5775000
[Hazard Note ]

Irritant
[HazardClass ]

6.1(a)
[PackingGroup ]

II
[HS Code ]

2928009090
Hazard InformationBack Directory
[Description]

FCCP (370-86-5) is an extremely potent uncoupler of mitochondrial oxidative phosphorylation (IC50 = 20 nM).1 Induces apoptosis in a variety of cell lines.2 Inhibits wild type and mutant beta-amyloid production in embryonic kidney 293 cells expressing either wild-type or “Swedish” mutant APP.3 An important tool for inhibiting mitochondrial membrane potential.2,4 Cell permeable.
[Uses]

A potent reversible inhibitor of mitochondrial oxidative phosphorylation. FCCP is a useful tool for depolarizing mitochondrial membrane potential. Treatment of cells with FCCP at varying concentrations leads to partial (100 nM) or complete (10 μM) depolarization and apoptosis.
[Uses]

FCCP is a potent uncoupler of oxidative phosphorylation in mitochondria that disrupts ATP synthesis by transporting protons across cell membranes. At 40 μM, FCCP induces complete depolymerization of microtubules by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the stability of microtubules by impairing the binding of microtubule-associated proteins.[Cayman Chemical]
[Definition]

ChEBI: A hydrazone that is hydrazonomalononitrile in which one of the hydrazine hydrogens is substituted by a p-trifluoromethoxyphenyl group.
[Biological Activity]

A very potent uncoupler of oxidative phosphorylation in mitochondria.
[Biochem/physiol Actions]

FCCP is a protonophore (H+ ionophore) and uncoupler of oxidative phosphorylation in mitochondria. It is capable of depolarizing plasma and mitochondrial membranes. FCCP has been shown to have a number of effects on cellular calcium. It also is reported to inhibit a background K+ current and induce a small inward current, reduce pH by 0.1 unit, and induce a rise of intracellular [Na+]. FCCP stimulates Mg2+-ATPase activity, inhibits β-amyloid production, and mimics the effect of selective glutamate agonist N-methyl-D-aspartate (NMDA) on mitochondrial superoxide production.
[in vitro]

fccp increases the rate of cellular o2 consumption. in pc-3 and du-145 prostate cancer cells, the compound could significantly decrease hypoxic as well as normoxic hif-1 transcriptional activity which was in part mediated by down-regulation of the oxygen labile hif-1α and hif-2α protein levels. during hypoxic as well as normoxic, it decreases the expression of hif target genes, vegf and vegf receptor-2. [2]
[in vivo]

fccp reduces mitochondrial membrane potential and atp production in 8-cell mouse embryos. also, the number of inner cell mass cells decrease within blastocysts with unchanged blastocyst development. this perturbed embryonic mitochondrial function is concomitant with reduced birth weight in female offspring following embryo transfer, which persists until weaning. although fccp-treated males also exhibits reduced glucose tolerance as female, their insulin sensitivity and adiposity gain between 4 and 14 weeks is unchanged. reducing mitochondrial function and, thus, decreasing atp output in the precompacting embryo can influence offspring phenotype. [3]
[storage]

Store at RT
[References]

1) Benz R & McLaughlin S, (1983). The molecular mechanism of action of the proton ionophore FCCP (carbonylcyanide p-trifluoromethoxyphenylhydrazone).; Biophys J 41 381 2) Gautier et al. (2000), A moderate but not total decrease of mitochondrial membrane potential triggers apoptosis in neuron-like cells.; Neuroreport 11 2953 3) Connop et al. (1999), Novel effects of FCCP [carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone] on amyloid precursor protein processing; J. Neurochem. 72 1457 4) Collins et al. (2000), Inositol 1,4,5-trisphosphate-induced Ca2+ release in inhibited by mitochondrial depolarization.; Biochem. J. 347 593
Spectrum DetailBack Directory
[Spectrum Detail]

FCCP(370-86-5)1HNMR
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